| Author | Delatorre, Edson | |
| Author | Fernandez, José C. Couto | |
| Author | Guimarães, Monick Lindenmeyer | |
| Author | Cardoso, Ludimila Paula Vaz | |
| Author | Alcantara, Keila Correia de | |
| Author | Stefani, Mariane Martins de Araújo | |
| Author | Romero, Hector | |
| Author | Freire, Caio C. M. | |
| Author | Iamarno, Atila | |
| Author | Zanotto, Paolo M. de A. | |
| Author | Morgado, Mariza G. | |
| Author | Bello, Gonzalo | |
| Access date | 2015-08-19T13:49:17Z | |
| Available date | 2015-08-19T13:49:17Z | |
| Document date | 2013 | |
| Citation | DELATORRE, Edson; et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. Plos One, v.8, n.9, 13p, 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11472 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Title | Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0074072 | pt_BR |
| Abstract | Previous studies indicate that the HIV-1 subtype C epidemic in southern Brazil was initiated by the introduction of a
single founder strain probably originating from east Africa. However, the exact country of origin of such a founder
strain as well as the origin of the subtype C viruses detected outside the Brazilian southern region remains unknown.
HIV-1 subtype C pol sequences isolated in the southern, southeastern and central-western Brazilian regions (n =
209) were compared with a large number (n ~ 2,000) of subtype C pol sequences of African origin. Maximumlikelihood
analyses revealed that most HIV-1 subtype C Brazilian sequences branched in a single monophyletic clade
(CBR-I), nested within a larger monophyletic lineage characteristic of east Africa. Bayesian analyses indicate that the
CBR-I clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around
the middle 1970s, after which it rapidly disseminated to neighboring regions. The states of Paraná and Santa
Catarina have been the most important hubs of subtype C dissemination, and routine travel and spatial accessibility
seems to have been the major driving forces of this process. Five additional introductions of HIV-1 subtype C strains
probably originated in eastern (n = 2), southern (n = 2) and central (n = 1) African countries were detected in the Rio
de Janeiro state (southeastern region). These results indicate a continuous influx of HIV-1 subtype C strains of
African origin into Brazil and also unveil the existence of unrecognized transmission networks linking this country to
east Africa. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Universidad de la República. Facultad de Ciencias. Sección Biomatemáticas. Laboratorio de Organización y Evolución del Genoma. Montevideo, Uruguay. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV-1 subtype C | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Origin and Northward Dissemination | pt_BR |
| DeCS | HIV-1 | pt_BR |
| DeCS | Brasil | pt_BR |
