Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/11472
Title: Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil
Authors: Delatorre, Edson
Fernandez, José C. Couto
Guimarães, Monick Lindenmeyer
Cardoso, Ludimila Paula Vaz
Alcantara, Keila Correia de
Stefani, Mariane Martins de Araújo
Romero, Hector
Freire, Caio C. M.
Iamarno, Atila
Zanotto, Paolo M. de A.
Morgado, Mariza G.
Bello, Gonzalo
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Universidad de la República. Facultad de Ciencias. Sección Biomatemáticas. Laboratorio de Organización y Evolución del Genoma. Montevideo, Uruguay.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, Brasil.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: Previous studies indicate that the HIV-1 subtype C epidemic in southern Brazil was initiated by the introduction of a single founder strain probably originating from east Africa. However, the exact country of origin of such a founder strain as well as the origin of the subtype C viruses detected outside the Brazilian southern region remains unknown. HIV-1 subtype C pol sequences isolated in the southern, southeastern and central-western Brazilian regions (n = 209) were compared with a large number (n ~ 2,000) of subtype C pol sequences of African origin. Maximumlikelihood analyses revealed that most HIV-1 subtype C Brazilian sequences branched in a single monophyletic clade (CBR-I), nested within a larger monophyletic lineage characteristic of east Africa. Bayesian analyses indicate that the CBR-I clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around the middle 1970s, after which it rapidly disseminated to neighboring regions. The states of Paraná and Santa Catarina have been the most important hubs of subtype C dissemination, and routine travel and spatial accessibility seems to have been the major driving forces of this process. Five additional introductions of HIV-1 subtype C strains probably originated in eastern (n = 2), southern (n = 2) and central (n = 1) African countries were detected in the Rio de Janeiro state (southeastern region). These results indicate a continuous influx of HIV-1 subtype C strains of African origin into Brazil and also unveil the existence of unrecognized transmission networks linking this country to east Africa.
Keywords: HIV-1 subtype C
Brazil
Origin and Northward Dissemination
DeCS: HIV-1
Brasil
Issue Date: 2013
Publisher: Plos One
Citation: DELATORRE, Edson; et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. Plos One, v.8, n.9, 13p, 2013.
DOI: 10.1371/journal.pone.0074072
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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