| Author | Trindade, Lucas S. | |
| Author | Aigaki, Toshiro | |
| Author | Peixoto, Alexandre A. | |
| Author | Balduíno, Alex | |
| Author | Cruz, Ivana B. Mânica | |
| Author | Heddle, Jonathan G. | |
| Access date | 2015-08-19T13:49:32Z | |
| Available date | 2015-08-19T13:49:32Z | |
| Document date | 2013 | |
| Citation | TRINDADE, Lucas S.; et al. A novel classification system for evolutionary aging theories. Frontiers in Genetics, v.4, Art.25, 8p, March 2013. | pt_BR |
| ISSN | 1664-802 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11558 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media S.A | pt_BR |
| Rights | open access | |
| Title | A novel classification system for evolutionary aging theories | pt_BR |
| Type | Article | |
| DOI | 10.3389/fgene.2013.00025 | pt_BR |
| Abstract | Theories of lifespan evolution are a source of confusion amongst aging researchers. After a century of aging research the dispute over whether the aging process is active or passive persists and a comprehensive and universally accepted theoretical model remains elusive. Evolutionary aging theories primarily dispute whether the aging process is exclusively adapted to favor the kin or exclusively non-adapted to favor the individual. Interestingly, contradictory data and theories supporting both exclusively programmed and exclusively non-programmed theories continue to grow. However, this is a false dichotomy; natural selection favors traits resulting in efficient reproduction whether they benefit the individual or the kin. Thus, to understand the evolution of aging, first we must understand the environment-dependent balance between the advantages and disadvantages of extended lifespan in the process of spreading genes. As described by distinct theories, different niches and environmental conditions confer on extended lifespan a range of fitness values varying from highly beneficial to highly detrimental. Here, we considered the range of fitness values for extended lifespan and develop a fitness-based framework for categorizing existing theories. We show that all theories can be classified into four basic types: secondary (beneficial), maladaptive (neutral), assisted death (detrimental), and senemorphic aging (varying between beneficial to detrimental). We anticipate that this classification system will assist with understanding and interpreting aging/death by providing a way of considering theories as members of one of these classes rather than consideration of their individual details. | pt_BR |
| Affilliation | Advanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, Japan / Nagasaki University. Graduate School of Biomedical Sciences. Department of Investigative Pathology. Nagasaki, Japan / Tokyo Metropolitan University. Department of Biological Sciences. Hachioji, Tokyo, Japanh. | pt_BR |
| Affilliation | Tokyo Metropolitan University, Department of Biological Sciences. Hachioji, Tokyo, Japan, | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Veiga de Almeida. Centro de Pesquisa em Desenvolvimento e Tecnologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Santa Maria. Centro de Ciências da Saúde. Departamento de Morfologia. Santa Maria, RS, Brasil. | pt_BR |
| Affilliation | Advanced Science Institute. Heddle Initiative Research Unit. Wako, Saitama, Japan | pt_BR |
| Subject | Senemorphism | pt_BR |
| Subject | Caloric restriction | pt_BR |
| Subject | Longevity | pt_BR |
| Subject | Altruism | pt_BR |
| Subject | Senescence | pt_BR |
| Subject | Evolution | pt_BR |
| DeCS | Envelhecimento | pt_BR |
| DeCS | Altruísmo | pt_BR |
| DeCS | Longevidade | pt_BR |
| DeCS | Restrição Calórica | pt_BR |
