| Author | Tavares, Luciana de Carvalho | |
| Author | Johann, Susana | |
| Author | Alves, Tânia Maria de Almeida | |
| Author | Guerra, Juliana Correia | |
| Author | Fagundes, Elaine Maria de Souza | |
| Author | Cisalpino, Patrícia Silva | |
| Author | Bortoluzzi, Adailton João | |
| Author | Caramori, Giovanni Finoto | |
| Author | Piccoli, Rafael de Mattos | |
| Author | Braibante, Hugo Tubal Schmitz | |
| Author | Braibante, Mara Elisa Fortes | |
| Author | Pizzolatti, Moacir Geraldo | |
| Access date | 2015-08-26T13:13:28Z | |
| Available date | 2015-08-26T13:13:28Z | |
| Document date | 2011 | |
| Citation | TAVARES, Luciana de Carvalho et al. Quinolinyl and quinolinyl N-oxide chalcones: Sinthesis, antifungal and cytotoxic activities. Journal of Medicinal Chemistry, vol. 46, n. 9, p. 4448-4456, 2011. | pt_BR |
| ISSN | 0223-5234 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11650 | |
| Language | eng | pt_BR |
| Publisher | Editions Scientifiques Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Quinolinyl and quinolinyl N-oxide chalcones: Sinthesis, antifungal and cytotoxic activities | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ejmech.2011.07.019 | |
| Abstract | A series of new 6-quinolinyl and quinolinyl N-oxide chalcones were efficiently prepared. All chalcones were tested by minimal inhibitory concentration (MIC) against three species of Candida, Cryptococcus gattii and Paracoccidioides brasiliensis. The effect of these compounds was also tested on the survival and growth of the human cancer cell lines UACC-62 (melanoma), MCF-7 (breast), TK-10 (renal) and leukemic cells, Jurkat and HL60. The compounds tested presented strong activity against P. brasiliensis, most importantly compound 4e. C. gattii also presented interesting susceptibility for compounds 5b and 5f. The cytotoxic activity showed that compounds 3c and 4e, presented the best activity against MCF-7 and TK-10. For leukemic cells the compounds4f, 3g, 4g and 5g have shown the best activity. | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/Laboratório de Química dos Produtos Naturais, Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Laboratório de Química dos Produtos Naturais, Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Maria. Departamento de Química. Santa Maria, RS, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Maria. Departamento de Química. Santa Maria, RS, Brazil | pt_BR |
| Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brazil | pt_BR |
| Subject | uinolinyl chalcones | pt_BR |
| Subject | Quinolinyl N-oxide chalcones | pt_BR |
| Subject | Cytotoxic activity | pt_BR |
| Subject | Antifungal activity | pt_BR |
