Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/11706
Title: A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention
Authors: Assis, Girley Francisco Machado de
Diniz, Gláucia Alessio
Montoya, Roberto Araújo
Dias, João Carlos Pinto
Coura, José Rodrigues
Coelho, George Luiz Lins Machado
Albajar-Viñas, Pedro
Torres, Rosália Morais
Lana, Marta de
Affilliation: Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Escola de Farmácia, Departamento de Análises Clínicas. Ouro Preto, MG, Brasil.
Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil.
Organização Pan-Americana da Saúde. Bogotá, Colômbia.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Médicas. Ouro Preto, MG, Brasil.
Organização Mundial da Saúde. Departamento de Controle de Doenças Tropicais Negligenciadas. Geneva, Switzerland.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.
Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil.
Abstract: The etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment. This study compares the laboratory and clinical evaluations of Chagas disease patients who were diagnosed 13 years earlier. Fifty-eight Chagas disease patients (29 treated with benznidazole and 29 untreated) were matched at the time of treatment based on several variables. Conventional serology revealed the absence of seroconversion in all patients. However, lower serological titres were verified in the treated group, primarily among patients who had the indeterminate form of the disease. Haemoculture performed 13 years after the intervention was positive for 6.9% and 27.6% of the treated and untreated patients, respectively. Polymerase chain reaction tests were positive for 44.8% and 13.8% of the treated and untreated patients, respectively. Patients who presented with the indeterminate form of the disease at the beginning of the study exhibited less clinical progression (17.4%) compared with the untreated group (56.5%). Therefore, this global analysis revealed that etiological treatment with benznidazole may benefit patients with respect to the clinical progression of Chagas disease and the prognosis, particularly when administered to patients with the indeterminate form of the disease.
Keywords: Chagas Disease
Benznidazole
Serological and clinical evaluation
Trypanosoma cruzi
Etiological treatment
DeCS: Trypanosoma cruzi
Doença de Chagas
Issue Date: 2013
Publisher: Fundação Oswaldo Cruz
Citation: ASSIS, Giley Francisco Machado de; et al. A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention. Mem Inst Oswaldo Cruz, v.108, n.7, p. 873-880, Nov. 2013.
DOI: 10.1590/0074-0276130122
ISSN: 1678-8060
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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