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HISTOPATHOLOGICAL FINDINGS OF AN UNCOMMON CO-INFECTION: ECHINOCOCCUS VOGELI, HIV, HEPATITIS C VIRUS, AND HEPATITIS B VIRUS
Almeida, Fernanda Barbosa de et al. | Date Issued: 2013
Author
Almeida, Fernanda Barbosa de
Corrêa, Christiane Leal
Siqueira, Nilton Ghiotti de
Carvalho, Nellysie Virgínia F. M. dos S. Castro de
Silva, Rosângela Rodrigues
Andrade, Arnaldo Feitosa B. de
Silva, Arnaldo Feitosa B. de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
Universidade Gama Filho. Laboratório de Patologia Experimental. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Acre, Rio Branco, AC, Brasil / Hospital da Fundação Estadual do Acre. Rio Branco, AC, Brasil.
Universidade Federal do Acre, Rio Branco, AC, Brasil / Hospital da Fundação Estadual do Acre. Rio Branco, AC, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.
Abstract
Our work represents the first case report of polycystic echinococcosis co-infection with HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV). Structural liver alterations were found to be related to parasitic structures and necroinflammatory foci (karyopyknosis, karyorrhexis, and karyolysis), consistent with Echinococcus vogeli. Visceral adipose tissue and intrahepatic triglyceride droplets (macrovesicular and microvesicular steatosis) indicated abnormal fat anabolism, which probably resulted from both viral- induced hepatopathy and drug-related toxicity. In summary, our results suggest that the observed liver abnormalities reflected the coincident exposure to hepatotropic viruses and parasites causing polycystic echinococcosis and were not indicative of opportunistic relationships among these pathogens.
Keywords
Co-infection
Polycystic echinococcosis
HIV
HCV
HBV
Echinococcus vogeli
 
DeCS
Vírus da Hepatite B
Sorodiagnóstico da AIDS
Hepacivirus
Echinococcus vogeli
 
Publisher
Elsevier
Citation
ALMEIDA, Fernanda Barbosa de; et al. Histopathological findings of an uncommon co-infection: Echinococcus vogeli, HIV, hepatitis C virus, and hepatitis B virus. International Journal of Infectious Diseases, v.17, n.10, e925–e927, 2013.
DOI
10.1016/j.ijid.2013.04.002
ISSN
1201-9712