| Author | Bastos, M. L. | |
| Author | Menzies, D. | |
| Author | Belo, M. T. C. T. | |
| Author | Teixeira, E. G. | |
| Author | Abreu, S. T. de | |
| Author | Antas, P. R. Z. | |
| Author | Trajman, A. | |
| Access date | 2015-09-21T17:25:49Z | |
| Available date | 2015-09-21T17:25:49Z | |
| Document date | 2013 | |
| Citation | BASTOS, M. L.; et al. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. The International Journal of Tuberculosis and Lung Disease, v.17, n.7, p.909-918, 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11789 | |
| Language | eng | pt_BR |
| Publisher | The Union | pt_BR |
| Rights | open access | |
| Title | Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection | pt_BR |
| Type | Article | |
| DOI | 10.5588/ijtld.12.0927 | pt_BR |
| Abstract | SETTING: Randomised trial comparing 9 months of
isoniazid with 4 months of rifampicin for the treatment
of high-risk tuberculin skin test positive subjects in Rio
de Janeiro, Brazil.
OBJECTIVES: To compare QuantiFERON®-TB Gold In-
Tube (QFT-GIT) responses before and 1, 4 and 9 months
after starting treatment for latent tuberculous infection
(LTBI) according to adherence to one of the two
regimens.
DESIGN: Participants in the trial were invited to undergo
serial QFT-GIT. Within-subject differences at different
time points were analysed as quantitative responses
and categorised as positive or negative using different
cut-off points.
RESULTS: Of 215 participants, 118 completed treatment,
of whom 58 underwent all three tests; and 97 did
not complete treatment, of whom 10 underwent all tests.
After 1 month of treatment, there was no significant difference
in QFT-GIT response between the groups. After
4 and 9 months, reversions were more frequent in nonadherent
subjects. Marked within-subject fluctuations
were observed. No cut-off point could be established at
which QFT-GIT responses were consistently positive or
associated with adherence or type of treatment.
CONCLUSION: Frequent within-subject variability in
QFT-GIT responses, not associated with LTBI treatment,
makes it difficult for clinicians to interpret QFT-GIT
conversions and reversions. | pt_BR |
| Affilliation | Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | McGill University. Montreal Chest Institute. Respiratory Epidemiology and Clinical Research Unit. Montreal, Quebec, Canada. | pt_BR |
| Affilliation | Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Souza Marques. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Souza Marques. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratório Pascoal Granato. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Gama Filho. Escola de Medicina. Programa de Pós-Gradução em Educação em Saúde. Rio de Janeiro, RJ, Brasil / Liga Científica de Tuberculose do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / | pt_BR |
| Affilliation | McGill University. Montreal Chest Institute. Respiratory Epidemiology and Clinical Research Unit. Montreal, Quebec, Canada. | pt_BR |
| Subject | Biomarker | pt_BR |
| Subject | Interferon-gamma assay | pt_BR |
| Subject | Serial testing | pt_BR |
| Subject | Latent tuberculosis | pt_BR |
| DeCS | Tuberculose | pt_BR |
| DeCS | Interferon gama | pt_BR |
| DeCS | Tuberculose Latente | pt_BR |
