| Author | Colares, Aracélio Viana | |
| Author | Souza, Fernando Almeida | |
| Author | Taniwaki, Noemi Nosomi | |
| Author | Souza, Celeste da Silva Freitas | |
| Author | Costa, José GalbertoMartins da | |
| Author | Calabrese, Kátia da Silva | |
| Author | Silva, Ana Lúcia Abreu | |
| Access date | 2015-09-21T17:25:53Z | |
| Available date | 2015-09-21T17:25:53Z | |
| Document date | 2013 | |
| Citation | COLARES, Aracélio Viana; et al. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine. v.2013, Article ID 727042, 7p, 2013. | pt_BR |
| ISSN | 1741-4288 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11799 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | |
| Title | In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker | pt_BR |
| Type | Article | |
| DOI | 10.1155/2013/727042 | pt_BR |
| Abstract | The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa,
such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active
ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent
discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea
(VAEO) and its major compound 𝛼-bisabolol against Leishmania amazonensis. The essential oil and 𝛼-bisabolol showed activity
against promastigotes (IC50 7.35 and 4.95 𝜇g/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 𝜇g/mL, resp.). Neither
product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or
𝛼-bisabolol at 30 𝜇g/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions.The results
give evidence that both VAEO and 𝛼-bisabolol have potential as new therapeutic agents against leishmaniasis. | pt_BR |
| Affilliation | Universidade Federal do Maranhão (UFMA). Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil / Faculdade Leão Sampaio (FALS). Juazeiro do Norte, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Adolf Lutz (IAL). Unidade de Microscopia Eletrônica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Regional do Cariri (URCA). Laboratório de Pesquisa de Produtos Naturais. Crato, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão (UEMA). Departamento de Patologia. São Luis, MA, Brasil. | pt_BR |
| Subject | Vanillosmopsis arborea | pt_BR |
| Subject | Asteraceae | pt_BR |
| Subject | In Vitro | pt_BR |
| Subject | Antileishmanial Activity | pt_BR |
| DeCS | Leishmaniose | pt_BR |
| DeCS | Asteraceae | pt_BR |
| DeCS | Técnicas In Vitro | pt_BR |
