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SEVERITY OF TEGUMENTARY LEISHMANIASIS IS NOT EXCLUSIVELY ASSOCIATED WITH LEISHMANIA RNA VIRUS 1 INFECTION IN BRAZIL
Pereira, Luiza de Oliveira Ramos et al. | Date Issued: 2013
Author
Pereira, Luiza de Oliveira Ramos
Mira, Ana Cláudia Maretti
Rodrigues, Káris Maria
Lima, Rosimar Baptista
Oliveira Neto, Manoel Paes de
Cupolillo, Elisa
Pirmez, Claude
Oliveira, Márcia Pereira de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
UCLA Medical. Los Angeles Biomedical Research Institute at Harbor. Department of Medicine. 2Divisions of Molecular Medicine. Los Angeles, CA, USA.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Abstract
Leishmania RNA virus (LRV) has been shown to be a symbiotic component of Leishmania parasites in South America. Nested retro-transcription polymerase chain reaction was employed to investigate LRV1 presence in leishmaniasis lesions from Brazil. In endemic areas of Rio de Janeiro (RJ), no LRV1 infection was observed even with mucosal involvement. LRV1 was only detected in Leishmania (V.) guyanensis cutaneous lesions from the northern region, which were obtained from patients presenting with disease reactivation after clinical cure of their primary lesions. Our results indicated that the severity of leishmaniasis in some areas of RJ, where Leishmania (V.) brazi- liensis is the primary etiological agent, was not associated with Leishmania LRV1 infection.
Keywords
Leishmania
LRV
Tegumentary leishmaniasis
Nested retro-transcription PCR
Brazil
 
DeCS
Leishmania
Virus de RNA
 
Publisher
Fundação Oswaldo Cruz
Citation
PEREIRA, Luiza de Oliveira Ramos; et al. Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil. Mem Inst Oswaldo Cruz, v.108, n.5, p. 665-667, Aug. 2013.
DOI
10.1590/0074-0276108052013021
ISSN
1678-8060