| Autor | Villar, Livia Melo | |
| Autor | Del Campo, José Antonio | |
| Autor | Ranchal, Isidora | |
| Autor | Lampe, Elisabeth | |
| Autor | Gomez, Manuel Romero | |
| Data de acesso | 2015-09-21T17:25:57Z | |
| Data de disponibilização | 2015-09-21T17:25:57Z | |
| Data do publicação | 2013 | |
| Citação | VILLAR, Livia Melo; Association between vitamin D and hepatitis C virus infection: A meta-analysis. World Journal of Gastroenterlogy, v.19, n.35, p.5917-5925, Sept. 2013. | pt_BR |
| ISSN | 1007-9327 | pt_BR |
| ISSN | 2219-2840 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11807 | |
| Idioma | eng | pt_BR |
| Editor | Baishideng | pt_BR |
| Direito Autoral | open access | |
| Palavras-chave | Terapia | pt_BR |
| Título | Association between vitamin D and hepatitis C virus infection: A meta-analysis | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.3748/wjg.v19.i35.5917 | pt_BR |
| Resumo em Inglês | AIM: To evaluate the association between 25-hydroxyvitamin
D [25(OH)D] and sustained virological
response (SVR) in hepatitis C virus (HCV) infected individuals.
METHODS: Relevant studies were identified by systematically
searching MEDLINE databases up to March
2012 and abstracts of the European and American Congress
of Hepatology conducted in 2011. Studies must
provide information on SVR and the levels of 25(OH)D3
and/or 25(OH)D2 [henceforth referred to as 25(OH)D]
in sera samples from HCV infected individuals. The inclusion
criteria were: clinical studies that included HCV
infected patients aged older than 18 years regardless of
HCV genotype or ethnic group; provided information on
SVR rates; and were reported in the English language
META-ANALYSIS
Online Submissions: http://www.wjgnet.com/esps/
wjg@wjgnet.com
doi:10.3748/wjg.v19.i35.5917
WJG|www.wjgnet.com 5917 September 21, 2013|Volume 19|Issue 35|
World J Gastroenterol 2013 September 21; 19(35): 5917-5924
ISSN 1007-9327 (print) ISSN 2219-2840 (online)
© 2013 Baishideng. All rights reserved.
as full papers. Due to the heterogeneity of studies in
categorizing serum vitamin D levels, a cut-off value of
30 ng/mL of serum 25(OH)D was used. Heterogeneity
was assessed using I 2 statistics. The summary odds
ratios with their corresponding 95%CI were calculated
based on a random-effects model.
RESULTS: Overall, 11 studies (8 observational and 3
interventional) involving 1575 individuals were included
and 1117 HCV infected individuals (71%) showed low
vitamin D levels. Most of the studies included monoinfected
HCV individuals with the mean age ranging
from 38 to 56 years. Four studies were conducted in
human immunodeficiency virus/HCV infected individuals.
Regarding vitamin D measurement, most of the
studies employed radioimmunoassays (n = 5) followed
by chemiluminescence (n = 4) and just one study employed
high performance/pressure liquid chromatography
(HPLC). Basal vitamin D levels varied from 17 to
43 ng/mL in the studies selected, and most of the HCV
infected individuals had genotype 1 (1068/1575) with
mean viral load varying from log 4.5-5.9 UI/mL. With
regard to HCV treatment, most of the studies (n = 8)
included HCV individuals without previous treatment,
where the pooled SVR rate was 46.4%. High rates of
SVR were observed in HCV individuals with vitamin D
levels above 30 ng/mL (OR = 1.57; 95%CI: 1.12-2.2)
and those supplemented with vitamin D (OR = 4.59;
95%CI: 1.67-12.63) regardless of genotype.
CONCLUSION: Our results demonstrated high prevalence
of vitamin D deficiency and high SVR in individuals
with higher serum vitamin D levels or receiving vitamin
D supplementation. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain. | pt_BR |
| Afiliação | Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain. | pt_BR |
| Palavras-chave em inglês | Vitamin D | pt_BR |
| Palavras-chave em inglês | Hepatitis C | pt_BR |
| Palavras-chave em inglês | Therapy | pt_BR |
| Palavras-chave em inglês | Meta-analysis | pt_BR |
| Palavras-chave em inglês | Sustained virological response | pt_BR |
| DeCS | Metanálise | pt_BR |
| DeCS | Vitamina D | pt_BR |
| DeCS | Hepatite C | pt_BR |
