Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/11807
Title: Association between vitamin D and hepatitis C virus infection: A meta-analysis
Authors: Villar, Livia Melo
Del Campo, José Antonio
Ranchal, Isidora
Lampe, Elisabeth
Gomez, Manuel Romero
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain.
Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Hospital Universitario de Valme. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Sevila, Spain.
Abstract: AIM: To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and sustained virological response (SVR) in hepatitis C virus (HCV) infected individuals. METHODS: Relevant studies were identified by systematically searching MEDLINE databases up to March 2012 and abstracts of the European and American Congress of Hepatology conducted in 2011. Studies must provide information on SVR and the levels of 25(OH)D3 and/or 25(OH)D2 [henceforth referred to as 25(OH)D] in sera samples from HCV infected individuals. The inclusion criteria were: clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group; provided information on SVR rates; and were reported in the English language META-ANALYSIS Online Submissions: http://www.wjgnet.com/esps/ wjg@wjgnet.com doi:10.3748/wjg.v19.i35.5917 WJG|www.wjgnet.com 5917 September 21, 2013|Volume 19|Issue 35| World J Gastroenterol 2013 September 21; 19(35): 5917-5924 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2013 Baishideng. All rights reserved. as full papers. Due to the heterogeneity of studies in categorizing serum vitamin D levels, a cut-off value of 30 ng/mL of serum 25(OH)D was used. Heterogeneity was assessed using I 2 statistics. The summary odds ratios with their corresponding 95%CI were calculated based on a random-effects model. RESULTS: Overall, 11 studies (8 observational and 3 interventional) involving 1575 individuals were included and 1117 HCV infected individuals (71%) showed low vitamin D levels. Most of the studies included monoinfected HCV individuals with the mean age ranging from 38 to 56 years. Four studies were conducted in human immunodeficiency virus/HCV infected individuals. Regarding vitamin D measurement, most of the studies employed radioimmunoassays (n = 5) followed by chemiluminescence (n = 4) and just one study employed high performance/pressure liquid chromatography (HPLC). Basal vitamin D levels varied from 17 to 43 ng/mL in the studies selected, and most of the HCV infected individuals had genotype 1 (1068/1575) with mean viral load varying from log 4.5-5.9 UI/mL. With regard to HCV treatment, most of the studies (n = 8) included HCV individuals without previous treatment, where the pooled SVR rate was 46.4%. High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL (OR = 1.57; 95%CI: 1.12-2.2) and those supplemented with vitamin D (OR = 4.59; 95%CI: 1.67-12.63) regardless of genotype. CONCLUSION: Our results demonstrated high prevalence of vitamin D deficiency and high SVR in individuals with higher serum vitamin D levels or receiving vitamin D supplementation.
Keywords: Vitamin D
Hepatitis C
Therapy
Meta-analysis
Sustained virological response
keywords: Terapia
DeCS: Metanálise
Vitamina D
Hepatite C
Issue Date: 2013
Publisher: Baishideng
Citation: VILLAR, Livia Melo; Association between vitamin D and hepatitis C virus infection: A meta-analysis. World Journal of Gastroenterlogy, v.19, n.35, p.5917-5925, Sept. 2013.
DOI: 10.3748/wjg.v19.i35.5917
ISSN: 1007-9327
2219-2840
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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