Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- INI - Artigos de Periódicos [3645]
- IOC - Artigos de Periódicos [12967]
- MG - IRR - Artigos de Periódicos [4307]
Metadata
Show full item record
MATRIX METALLOPROTEINASES 2 AND 9 ARE DIFFERENTIALLY EXPRESSED IN PATIENTS WITH INDETERMINATE AND CARDIAC CLINICAL FORMS OF CHAGAS DISEASE
Author
Affilliation
Abstract
Dilated chronic cardiomyopathy (DCC) from Chagas disease is associated with myocardial remodeling and interstitial fibrosis,
resulting in extracellular matrix (ECM) changes. In this study, we characterized for the first time the serum matrix metalloproteinase
2 (MMP-2) and MMP-9 levels, as well as their main cell sources in peripheral blood mononuclear cells from patients presenting
with the indeterminate (IND) or cardiac (CARD) clinical form of Chagas disease. Our results showed that serum levels of
MMP-9 are associated with the severity of Chagas disease. The analysis of MMP production by T lymphocytes showed that CD8
T cells are the main mononuclear leukocyte source of both MMP-2 and MMP-9 molecules. Using a new 3-dimensional model of
fibrosis, we observed that sera from patients with Chagas disease induced an increase in the extracellular matrix components in
cardiac spheroids. Furthermore, MMP-2 and MMP-9 showed different correlations with matrix proteins and inflammatory cytokines
in patients with Chagas disease. Our results suggest that MMP-2 and MMP-9 show distinct activities in Chagas disease
pathogenesis. While MMP-9 seems to be involved in the inflammation and cardiac remodeling of Chagas disease, MMP-2 does
not correlate with inflammatory molecules.
Share