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FAMILIAL AGGREGATION OF MUCOSAL LEISHMANIASIS IN NORTHEAST BRAZIL.
Castellucci, Léa Cristina de Carvalho et al. | Date Issued: 2005
Author
Castellucci, Léa Cristina de Carvalho
Cheng, Lay Har
Araujo, Cibele
Guimarães, Luiz Henrique Santos
Lessa, Helio
Machado, Paulo Roberto Lima
Andrade, Mirela Frederico de Almeida
Oliveira, Adja da Silva
Ko, Albert Icksang
Johnson, Warren D
Wilson, Mary E
Carvalho Filho, Edgar Marcelino
Jesus, Amélia Maria Ribeiro de
Affilliation
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Cornell University. Weill Medical College of New York. Medicine and Infectious Diseases. Division of International. New York, NY
University of Iowa. Departments of Internal Medicine and Microbiology. Iowa City, Iowa
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Abstract
To evaluate whether familial clustering occurs in mucosal leishmaniasis (ML), patients with ML (index cases) were randomly selected from medical records at a health post in an endemic area for Leishmania braziliensis infection. Control individuals (index controls) matched by age, gender, and place of residence to index cases were selected. Family members of index cases and controls were compared with respect to environmental factors and the incidence of cutaneous leishmaniasis (CL) and ML. Delayed type hypersensitivity test (DTH) to Leishmania antigen was tested in selected families. Among 289 members of 46 families enrolled, significant differences were found in the frequencies of CL (37% versus 20%) and ML (5% versus 0) in case versus control families, respectively. Families with 2 cases of ML had a higher frequency (29.6%) of DTH-positive individuals than control families (9.4%). These data demonstrate familial clustering of CL, ML, and positive DTH skin tests in an area endemic for L. braziliensis infection.
DeCS
Leishmaniose Mucocutânea/epidemiologia
Adulto
Animais
Brasil/epidemiologia
Criança
Eletricidade
Exposição Ambiental
Familia
Feminino
Habitação
Humanos
Leishmania braziliensis
Leishmaniose Mucocutânea/transmissão
Masculino
Núcleo Familiar
Ocupações
Linhagem
Testes Cutâneos
 
Publisher
American Society of Tropical Medicine and Hygiene
Citation
CASTELLUCCI, L. C. C. et al. Familial aggregation of mucosal leishmaniasis in northeast Brazil. American Journal of Tropical Medicine and Hygiene, v. 73, n. 1, p. 69-73, 2005.
ISSN
0002-9637