| Author | Silva, Marcelle Figueira Marques da | |
| Author | Rose, Tatiana Lundgren | |
| Author | Gómez, Mariela Martínez | |
| Author | Costa, Filipe Anibal Carvalho | |
| Author | Fialho, Alexandre Madi | |
| Author | Assis, Rosane Maria Santos de | |
| Author | Andrade, Juliana da Silva Ribeiro de | |
| Author | Volotão, Eduardo de Mello | |
| Author | Leite, José Paulo Gagliardi | |
| Access date | 2015-10-27T11:26:50Z | |
| Available date | 2016-03-01T07:30:08Z | |
| Document date | 2015 | |
| Citation | SILVA, Marcelle Figueira Marques da; et al. G1P[8] species A rotavirus over 27 years – Pre- and post-vaccination eras – in Brazil: Full genomic constellation analysis and no evidence for selection pressure by Rotarix vaccine. Infection, Genetics and Evolution, v.30, p.206–218, March 2015. | pt_BR |
| ISSN | 1567-1348 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12089 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Title | G1P[8] species A rotavirus over 27 years – Pre- and post-vaccination eras – in Brazil: Full genomic constellation analysis and no evidence for selection pressure by Rotarix vaccine | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.meegid.2014.12.030 | |
| Abstract | Epidemiological data on species A rotavirus (RVA) infections have demonstrated the genetic diversity of
strains circulating worldwide. Many G and P genotype combinations have been described over the years,
varying regionally and temporally, especially in developing countries. However, the most common G and
P genotype combinations identified in RVA human strains worldwide are G1P[8], G2P[4], G3P[8], G4P[8]
and G9P[8]. RVA genotype G1P[8] strains are responsible for more than 50% of child infections worldwide
and component of the two vaccines (Rotarix [RV1] and RotaTeq [RV5]) licensed globally. For a better
understanding of the evolutionary mechanisms of this genotype in Brazil, phylogenetic analyses based
on the 11 RVA genome segments (genomic constellation) from 90 G1P[8] RVA strains collected in two
eras – (i) pre-vaccination with RV1 (1996–February 2006); (ii) post-vaccination (March 2006–2013) –
in different Brazilian states were performed. The results showed the Wa-like genomic constellation of
the Brazilian G1P[8] strains with a I1-R1-C1-M1-A1-N1-T1-E1-H1 specificity, except for two strains
(rj14055-07 and ba19030-10) that belong to a I1-R1-C1-M1-A1-N1-T3-E1-H1 genomic constellation, evidencing
the occurrence of reassortment (Wa-like AU-1-like) of the NSP3 gene. Reassortment events
were also demonstrated between Brazilian G1P[8] strains and the RV1 vaccine strain in some genes in
vaccinated and unvaccinated children. VP7 and VP8* antigenic site analysis showed that the amino acid
substitutions observed in samples collected after the introduction of RV1 in Brazil were already detected
in samples collected in the 1980s and 1990s, suggesting that mass Brazilian RV1 vaccination had no
impact on the diversity observed inside antigenic sites for these two proteins. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Acute gastroenteritis | pt_BR |
| Subject | Species A rotavirus | pt_BR |
| Subject | G1P[8] genomic constellation | pt_BR |
| Subject | Rotarix vaccine | pt_BR |
| Subject | Reassortment | pt_BR |
| DeCS | Gastroenterite | pt_BR |
| DeCS | Rotavirus | pt_BR |
| Embargo date | 2016-02-29 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
