Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12095
Title: Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil
Authors: Silva, D. S. Perce da
Silva, L. A.
Lima Junior, J. C.
Oliveira, J. Cardoso
Alves, M. RIbeiro
Santos, F.
Porto, L. C. M. S.
Ferreira, J. Oliveira
Banic, D. M.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Referência Nacional em Simulídeos e Oncocercose. Pesquisa em Malária e Oncocerciase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Referência Nacional em Simulídeos e Oncocercose. Pesquisa em Malária e Oncocerciase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Infectologia. Centro de Pesquisa Clínica em HIV/AIDS. Rio de Janeiro, RJ, Brasil.
Laboratório de Entomologia (LACEN). Rondônia, Brasil.
Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Referência Nacional em Simulídeos e Oncocercose. Pesquisa em Malária e Oncocerciase. Rio de Janeiro, RJ, Brasil.
Abstract: Killer cell immunoglobulin-like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi-ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy-five KIR–HLA pair combinations were identified. The KIR-2DL2/3_HLA-C1, KIR3DL1_HLA-Bw4 and KIR2DL1_HLA-C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.
Keywords: Human leukocyte antigen
Brazil
Killer cell immunoglobulin-like receptor (KIR)
Malaria
DeCS: Malária
Antígenos HLA
Brasil
Receptores KIR
Issue Date: 2015
Publisher: John Wiley & Sons
Citation: SILVA, D. S. Perce da; et al. Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil. Tissue Antigens, v. 85, p.190–199, 2015.
DOI: 10.1111/tan.12523
ISSN: 0001-2815
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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