| Author | Ko, Albert Icksang | |
| Author | Goarant, Cyrille | |
| Author | Picardeau, Mathieu | |
| Access date | 2015-11-13T12:47:49Z | |
| Available date | 2015-11-13T12:47:49Z | |
| Document date | 2009 | |
| Citation | HO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009. | pt_BR |
| ISSN | 1740-1534 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12224 | |
| Language | eng | pt_BR |
| Publisher | Nature Publishing Group | pt_BR |
| Rights | open access | pt_BR |
| Title | Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/nrmicro2208. | |
| Abstract | Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis. | pt_BR |
| Affilliation | Weill Medical College of Cornell University. Division of Infectious Disease. New York, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Institut Pasteur de Nouvelle-Calédonie. Laboratoire de Recherche en Bactériologie. Nouméa, New-Caledonia | pt_BR |
| Affilliation | Institut Pasteur. Unité de Biologie des Spirochètes. Paris, France | pt_BR |
| DeCS | Leptospira/genética | pt_BR |
| DeCS | Leptospira/patogenicidade | pt_BR |
| DeCS | Leptospirose/microbiologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Vacinas Bacterianas/imunologia | pt_BR |
| DeCS | Modelos Animais de Doenças | pt_BR |
| DeCS | Genoma Bacteriano | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Leptospira/crescimento & desenvolvimento | pt_BR |
| DeCS | Leptospira/imunologia | pt_BR |
| DeCS | Leptospirose/epidemiologia | pt_BR |
| DeCS | Leptospirose/prevenção & controle | pt_BR |
| DeCS | Leptospirose/transmissão | pt_BR |
| DeCS | Virulência | pt_BR |
