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Title: Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Authors: Ko, Albert Icksang
Goarant, Cyrille
Picardeau, Mathieu
Affilliation: Weill Medical College of Cornell University. Division of Infectious Disease. New York, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur de Nouvelle-Calédonie. Laboratoire de Recherche en Bactériologie. Nouméa, New-Caledonia
Institut Pasteur. Unité de Biologie des Spirochètes. Paris, France
Abstract: Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.
DeCS: Leptospira/genética
Vacinas Bacterianas/imunologia
Modelos Animais de Doenças
Genoma Bacteriano
Leptospira/crescimento & desenvolvimento
Leptospirose/prevenção & controle
Issue Date: 2009
Publisher: Nature Publishing Group
Citation: HO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009.
DOI: 10.1038/nrmicro2208.
ISSN: 1740-1534
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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