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BIOFILM PRODUCTION BY MULTIRESISTANT CORYNEBACTERIUM STRIATUM ASSOCIATED WITH NOSOCOMIAL OUTBREAK
Corynebacterium striatum
Epidemic clone
Fibrinogen
Multi-resistance
Nosocomial outbreak
Author
Affilliation
Abstract
Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However,
little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We
investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible
(MDS) strains of C. striatum of pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS and IV-MDS isolated
during a nosocomial outbreak in Rio de Janeiro, Brazil. The results showed that C. striatum was able to adhere
to hydrophilic and hydrophobic abiotic surfaces. The C. striatum 1987/I-MDR strain, predominantly isolated from
patients undergoing endotracheal intubation procedures, showed the greatest ability to adhere to all surfaces. C.
striatum bound fibrinogen to its surface, which contributed to biofilm formation. Scanning electron microscopy
showed the production of mature biofilms on polyurethane catheters by all pulsotypes. In conclusion, biofilm production
may contribute to the establishment of HAIs caused by C. striatum.
Keywords in Portuguese
Ingfecção hospitalarKeywords
BiofilmCorynebacterium striatum
Epidemic clone
Fibrinogen
Multi-resistance
Nosocomial outbreak
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