Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12273
Title: Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis
Authors: Alvarado-Amez, Lucia Elena
Amaral, Evaldo P.
Marques, Carolinne Sales
Durães, Sandra M. B.
Cardoso, Cynthia C.
Sarno, Euzenir Nunes
Pacheco, Antonio G.
Lana, Francisco C. F.
Moraes, Milton Ozório
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Departamento de Enfermagem Materno-Infantil e Saúde Pública. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Medicina Clínica. Serviço de Dermatologia. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Departamento de Enfermagem Materno-Infantil e Saúde Pública. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Abstract: Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine inmycobacterial pathogenesis and especially the -819C>TSNP (rs1800871) has been tested in several case-control studies indicating association with leprosy risk, although a recent consensus estimate is stillmissing. In this study, we evaluated the association of the -819C>T SNP and leprosy in two new Brazilian family-based populations. Then, we performed meta-analysis for this polymorphism summarizing published studies including these Brazilian family-based groups. Finally, we also retrieved published studies for other distal and proximal IL10 polymorphisms: -3575 T>A (rs1800890), -2849 G>A (rs6703630), -2763 C>A (rs6693899), -1082 G>A (rs1800896) and -592 C>A (rs1800872). Results from metaanalysis supported a significant susceptibility association for the -819T allele, with pooled OddsRatio of 1.22 (CI = 1.11–1.34) and P-value = 3x10–5 confirming previous data. This result remained unaltered after inclusion of the Brazilian family-based groups (OR = 1.2, CI = 1.10–1.31, P-value = 2x10–5). Also,meta-analysis confirmed association of -592 A allele and leprosy outcome (OR = 1.24, CI = 1.03–1.50, P-value = 0.02). In support of this, linkage disequilibrium analysis in 1000 genomes AFR, EUR, ASN and AMR populations pointed to r2 = 1.0 between the -592C>A and -819C>T SNPs. We found no evidence of association for the other IL10 polymorphisms analyzed for leprosy outcome. Our results reinforce the role of the -819C>T as a tag SNP (rs1800871) and its association with leprosy susceptibility.
Keywords: Leprosy
Chronic infectious disease
IL10 Polymorphisms
Interleukin-10
DeCS: Hanseníase
Doença Crônica
Interleucina-10
Issue Date: 2015
Publisher: Plos One
Citation: ALVARADO-AMEZ, Lucia Elena et al. Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis. Plos One, v. 10, n. 9, p. 1-13, Sept. 2015.
DOI: 10.1371/journal.pone.0136282
ISSN: 1932-6203
Copyright: open access
Appears in Collections:Presidência Fiocruz - PROCC - Artigos de Periódicos
IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
euzenir_sarno_etal_IOC_2015.pdf677.22 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.