Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12361
Title: Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil
Authors: Delatorre, Edson
Castro, Carlos A. Velasco de
Pilotto, José H.
Fernandez, José Carlos Couto
Bello, Gonzalo
Morgado, Mariza G.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Patologia Clínica. Laboratório de Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from Sa˜o Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n = 212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979–1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.
Keywords: HIV-1
Brazil
HIV-1 CRF02_AG Lineages
keywords: HIV-1
Brasil
Rio de Janeiro
Issue Date: 2015
Publisher: Mary Ann Liebert
Citation: DELATORRE, Edson; et al. Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil. AIDS Research and Human Retroviruses, v.31, n.12, Nov. 2015.
DOI: 10.1089/aid.2015.0183
ISSN: 0889-2229
Embargo date: 2016-12
Copyright: restricted access
Appears in Collections:IFF - Artigos de Periódicos
IOC - Artigos de Periódicos

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