| Author | Araujo, Isabel Inês M. de Pina | |
| Author | Delatorre, Edson | |
| Author | Guimarães, Monick L. | |
| Author | Morgado, Mariza G. | |
| Author | Bello, Gonzalo | |
| Access date | 2015-12-08T15:10:30Z | |
| Available date | 2015-12-08T15:10:30Z | |
| Document date | 2015 | |
| Citation | ARAUJO, Isabel Inês M. de; et al. Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal. Plos One, v.10, n.5, e0127384, 16p, May 2015. | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12362 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cabo Verde | pt_BR |
| Subject in Portuguese | Portugal | pt_BR |
| Subject in Portuguese | HIV - 1 | pt_BR |
| Subject in Portuguese | Dinâmica Populacional | pt_BR |
| Title | Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0127384 | |
| Abstract | The human immunodeficiency virus type 1 (HIV-1) subtype G is the most prevalent and
second most prevalent HIV-1 clade in Cape Verde and Portugal, respectively; but there is
no information about the origin and spatiotemporal dispersal pattern of this HIV-1 clade
circulating in those countries. To this end, we used Maximum Likelihood and Bayesian coalescent-based
methods to analyze a collection of 578 HIV-1 subtype G pol sequences sampled
throughout Portugal, Cape Verde and 11 other countries from West and Central Africa
over a period of 22 years (1992 to 2013). Our analyses indicate that most subtype G sequences
from Cape Verde (80%) and Portugal (95%) branched together in a distinct monophyletic
cluster (here called GCV-PT). The GCV-PT clade probably emerged after a single
migration of the virus out of Central Africa into Cape Verde between the late 1970s and the
middle 1980s, followed by a rapid dissemination to Portugal a couple of years later. Reconstruction
of the demographic history of the GCV-PT clade circulating in Cape Verde and Portugal
indicates that this viral clade displayed an initial phase of exponential growth during
the 1980s and 1990s, followed by a decline in growth rate since the early 2000s. Our data
also indicate that during the exponential growth phase the GCV-PT clade recombined with a
preexisting subtype B viral strain circulating in Portugal, originating the CRF14_BG clade
that was later disseminated to Spain and Cape Verde. Historical and recent human population
movements between Angola, Cape Verde and Portugal probably played a key role in
the origin and dispersal of the GCV-PT and CRF14_BG clades. | pt_BR |
| Affilliation | Universidade de Cabo Verde. Departamento de Ciência e Tecnologia. Praia, Santiago, Cabo Verde. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV-1 Subtype G | pt_BR |
| Subject | Cape Verde | pt_BR |
| Subject | Portugal | pt_BR |
| Subject | Population Dynamics | pt_BR |
