Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12537
Title: Virological surveillance for early warning of dengue epidemics in the State of Rio de Janeiro, Brazil
Authors: Macedo, Gleicy Amorim
Araújo, Josélio Maria Galvão de
Schatzmayr, Hermann Gonçalves
Costa, Filipe Anibal Carvalho
Filippis, Ana Maria Bispo de
Santos, Flávia Barreto dos
Nogueira, Rita Maria Ribeiro
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio Grande do Norte. Laboratório de Biologia Molecular para Doenças Infecciosas e Câncer. Natal, RN, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Abstract: Background: The state of Rio de Janeiro has been important since 1986 as a portal for the introduction of dengue virus (DENV) into Brazil and dissemination of the virus throughout the country. This study describes an active surveillance of DENV in the state of Rio de Janeiro from 2004 to 2008. Method: A total of 14 408 samples from patients suspected to be infected with DENV were tested by virus isolation, and nested reverse transcriptase (RT)-PCR assay or anti-DENV dengue IgM antibody capture ELISA (MAC-ELISA), or both. Results: By the use of these different methods, a total of 2324 (16.1%) cases were confirmed as dengue infection. The study covers an inter-epidemic period (2004–2005), the DENV-3 circulation in 2006, the re-emergence of DENV-2 in 2007 and the severe epidemic caused by DENV-2 in the summer of 2008. During the period, 69 dengue fatal cases were reported, 14 (20.2%) deaths being attributable to DENV-3 and 55 (79.7%) to DENV-2. Conclusion: Our results emphasize the role of the laboratory in the early detection of dengue virus transmission and provide information on the dynamics of DENV introduction and spread, important for the assessment of intervention strategies.
Keywords: Dengue virus
Brazil
Surveillance
DeCS: Virus da Dengue
Brazil
Vigilância
Issue Date: 2013
Publisher: Oxford University Press
Citation: MACEDO, Gleicy Amorim; et al. Virological surveillance for early warning of dengue epidemics in the State of Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg., v.107, n.3, p.141-6, Mar. 2013.
DOI: 10.1093/trstmh/trs091
ISSN: 0035-9203
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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