| Author | Silva, Jaquelline Carla Valamiel de Oliveira | |
| Author | Assis, Girley Francisco Machado de | |
| Author | Oliveira, Maykon Tavares | |
| Author | Paiva, Nívia Carolina Nogueira | |
| Author | Araújo, Márcio Sobreira Silva | |
| Author | Carneiro, Cláudia Martins | |
| Author | Martins Filho, Olindo Assis | |
| Author | Martins, Helen Rodrigues | |
| Author | Lana, Marta de | |
| Access date | 2016-01-20T14:27:56Z | |
| Available date | 2016-01-20T14:27:56Z | |
| Document date | 2015 | |
| Citation | SILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12567 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | pt_BR |
| Title | Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-02760140260 | |
| Abstract | Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region. | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Faculdade de Ciências Biológicas e da Saúde. Departamento de Farmácia. Teófilo Otoni, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil | pt_BR |
| Subject | Trypanosoma cruzi II | pt_BR |
| Subject | benznidazole response | pt_BR |
| Subject | acute and chronic phases | pt_BR |
| Subject | murine model | pt_BR |
| Subject | Jequitinhonha Valley - MG - Brazil | pt_BR |
