Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12567
Title: Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
Authors: Silva, Jaquelline Carla Valamiel de Oliveira
Assis, Girley Francisco Machado de
Oliveira, Maykon Tavares
Paiva, Nívia Carolina Nogueira
Araújo, Márcio Sobreira Silva
Carneiro, Cláudia Martins
Martins Filho, Olindo Assis
Martins, Helen Rodrigues
Lana, Marta de
Affilliation: Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
Universidade Federal dos Vales do Jequitinhonha e Mucuri. Faculdade de Ciências Biológicas e da Saúde. Departamento de Farmácia. Teófilo Otoni, MG, Brasil
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil
Abstract: Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.
Keywords: Trypanosoma cruzi II
benznidazole response
acute and chronic phases
murine model
Jequitinhonha Valley - MG - Brazil
Issue Date: 2015
Publisher: Fundação Oswaldo Cruz
Citation: SILVA, Jaquelline Carla Valamiel de Oliveira et al. Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease. Mem Inst Oswaldo Cruz, Vol. 110, n. 1, p. 86-94, 2015.
DOI: 10.1590/0074-02760140260
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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