Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12648
Title: Antihypertensive Treatment Improves Microvascular Rarefaction and Reactivity in Low-Risk Hypertensive Individuals
Authors: Kaiser, Sérgio E.
Sanjuliani, Antonio F.
Estato, Vanessa
Gomes, Marilia B.
Tibiriçá, Eduardo
Affilliation: Universidade do Estado do Rio de Janeiro. Unidade de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Unidade de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Rio de Janeiro, RJ, Braisl.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Abstract: To test whether long-term antihypertensive treatment with metoprolol succinate (a β₁-adrenoceptor blocker) or olmesartan medoxomil (an angiotensin II AT₁-receptor blocker) reverses microvascular dysfunction in hypertensive patients. METHODS: This study included 44 hypertensive outpatients and 20 age and sex-matched healthy controls. We used skin capillaroscopy to measure capillary density and recruitment at rest and during PORH. Endothelium-dependent vasodilation of skin microcirculation was evaluated with a LDPM system in combination with ACh iontophoresis, PORH, and LTH. RESULTS: Pretreatment capillary density in hypertensive patients was significantly reduced compared with controls (71.3 ± 1.5 vs. 80.6 ± 1.8 cap/mm²; p < 0.001), as was PORH (71.7 ± 1.5 vs. 79.5 ± 2.6 cap/mm²; p < 0.05). After treatment for six months, capillary density increased to 75.4 ± 1.1 cap/mm² (p < 0.01) at rest and 76.8 ± 1.1 cap/mm² during PORH. During LTH, CVC in perfusion units (PU)/mmHg was similar in patients (1.71 [1.31-2.12]) and controls (1.60 [1.12-1.91]) and increased significantly (1.82 [1.30-2.20]) after treatment. Maximal CVC during PORH was reduced in hypertensive patients (0.30 [0.22-0.39]) compared to controls (0.39 [0.31-0.49], p < 0.001) and increased (0.41 [0.29-0.51], p < 0.001) after treatment. CONCLUSIONS: Capillary rarefaction and microvascular endothelial dysfunction in hypertensive patients responded favorably to long-term pharmacological treatment.
Keywords: Capillary rarefaction
Hypertension
Microvascular disfunction
video capillaroscopy
keywords: Vídeo capilaroscopia
Disfunção microvascular
Rarefação capilar
Hipertensão
Issue Date: 2013
Publisher: Wiley
Citation: KAISER, Sérgio E. et al. Antihypertensive Treatment Improves Microvascular Rarefaction and Reactivity in Low-Risk Hypertensive Individuals. Microcirculation, v.20, n.8, p.703-716, 2013.
DOI: 10.1111/micc.12067
ISSN: 1073-9688
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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