Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12973]
Metadata
Show full item record
TRYPANOSOMA CRUZI ENTRANCE THROUGH SYSTEMIC OR MUCOSAL INFECTION SITES DIFFERENTIALLY MODULATES REGIONAL IMMUNE RESPONSE FOLLOWING ACUTE INFECTION IN MICE
Author
Affilliation
Abstract
Acute Chagas disease is characterized by a systemic infection that leads to the strong activation
of the adaptive immune response. Outbreaks of oral contamination by the infective
protozoan Trypanosoma cruzi are frequent in Brazil and other Latin American countries,
and an increased severity of clinical manifestations and mortality is observed in infected
patients. These findings have elicited questions about the specific responses triggered
after T. cruzi entry via mucosal sites, possibly modulating local immune mechanisms, and
further impacting regional and systemic immunity. Here, we provide evidence for the existence
of differential lymphoid organ responses in experimental models of acute T. cruzi
infection.
Share