| Author | Oliveira, Maria de Lourdes Aguiar | |
| Author | Yoshida, Clara Fumiko Tachibana | |
| Author | Dias, Paulo Roberto Telles Pires | |
| Author | Vilas-Boas Hacker, Mariana de Andrea | |
| Author | Oliveira, Sabrina Alberti Nóbrega de | |
| Author | Miguel, Juliana Custódio | |
| Author | Ó, Kycia Maria Rodrigues do | |
| Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Access date | 2010-11-05T17:00:06Z | |
| Available date | 2010-11-05T17:00:06Z | |
| Document date | 2009 | |
| Citation | Epidemiol. Infect. 137, 970–979, 2009 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/1275 | |
| Description | This paper is based on data from two cross-sectional
studies: Projeto Brasil, a multicentre study carried out
from 1994–1997 to estimate prevalence of HIV and
viral hepatitis in five Brazilian cities and the WHO
Drug Injection Study Phase II – a project, coordinated
and sponsored by the World Health Organization and
implemented by the WHO Phase II Drug Injection
Collaborative Study Group. The authors alone are
responsible for the views expressed in this paper,
which do not necessarily represent those of the
other investigators participating in the WHO Drug
Injection Study Phase II nor the views or policy of the
World Health Organization. The Brazilian component
of the study was sponsored by WHO, as well as
by the Coordenac¸ a˜ o Geral de Laborato´ rios, National
Health Foundation, SVS, Ministry of Health, Brazil
and Conselho Nacional de Desenvolvimento Cientı´ -
fico e Tecnolo´ gico, CNPq, Grant no. 475668/03. We
are grateful to Genomic Platform-DNA Sequencing
(PDTIS-Fiocruz) for DNA sequencing of samples
included in this study. | en_US |
| Language | eng | en_US |
| Publisher | Cambridge University Press | en_US |
| Rights | open access | en_US |
| Title | Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies | en_US |
| Type | Article | en_US |
| DOI | 10.1017/S0950268808001970 | |
| Abstract | In the last decade, a declining prevalence of HCV infection has been described in injecting drug
users (IDUs) in different countries. This study is the first to assess temporal trends in druginjecting
patterns, HCV infection rates and viral genotype distribution in 770 Brazilian IDUs,
recruited by two cross-sectional studies (1994–1997 and 1999–2001). A substantial decline in the
prevalence of HCV infection was found over the years (75% in 1994 vs. 20 . 6% in 2001,
P<0.001) that may be a consequence of the significant reduction in the overall frequencies of
drug injection and needle-sharing, as well as the participation of IDUs in initiatives aimed at
reducing drug-related harm. No trend was found in terms of viral genotype distribution. Despite
the favourable scenario, preventive measures must be maintained, especially in vulnerable
subgroups such as young or new injectors, where risky behaviours through direct and indirect
sharing practices remain common. | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis and National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | Center for Drug Abuse Treatment and Research (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, Brazil | en_US |
| Affilliation | Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | Department of Health Information, Center for Information on Science and Technology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Subject | Hepatitis C | en_US |
| Subject | infectious disease epidemiology | en_US |
| Subject | injecting drug use | en_US |
| Subject | molecular epidemiology | en_US |
