Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12808
Title: Mixed infection of Leishmania infantum and Leishmania braziliensis in rodents from endemic urban area of the New World
Authors: Ferreira, Eduardo de Castro
Cruz, Israel
Cañavate, Carmen
Melo, Lutiana Amaral de
Pereira, Agnes Antônia Sampaio
Madeira, Filipe A M
Valério, Sofia Alves Nogueira
Cunha, Heitor Morais
Paglia, Adriano Pereira
Gontijo, Célia Maria Ferreira
Affilliation: Fundação Oswaldo Cruz. Fundação Oswaldo Cruz Mato Grosso do Sul. Campo Grande, MS, Brasil.
WHO Collaborating Center for Leishmaniasis. Servicio de Parasitología. Centro Nacional de Microbiología. Instituto de Salud Carlos III, Madri, Espanha.
WHO Collaborating Center for Leishmaniasis. Servicio de Parasitología. Centro Nacional de Microbiología. Instituto de Salud Carlos III, Madri, Espanha.
Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Serviço de Biologia Molecular e Bioinformática. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Estudos em Leishmanioses. Belo Horizonte, MG, Brasil.
Sete Soluções e Tecnologias Ambientais. Belo Horizonte, MG, Brasil.
Prefeitura de Belo Horizonte. Secretaria de Saúde de Belo Horizonte, Belo Horizonte, MG, Brasil.
Sete Soluções e Tecnologias Ambientais. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Estudos em Leishmanioses. Belo Horizonte, MG, Brasil.
Abstract: BACKGROUND: In Brazil Leishmania braziliensis and L. infantum are the principal species responsible for cutaneous and visceral leishmaniases, respectively. Domestic dogs are the main reservoirs of visceral leishmaniasis, while rodents and marsupials are the main reservoirs for cutaneous leishmaniasis. It has also been suggested that dogs could play a role in transmission of cutaneous leishmaniasis. The identification of the species of Leishmania, the reservoirs, and the vectors involved in each particular transmission cycle is critical for the establishment of control activities. Belo Horizonte has emerged as an endemic region for leishmaniases, however, epidemiological studies assessing the contribution of wild reservoirs to transmission are scarce in the area. The aim of this study was to investigate Leishmania spp. infection in possible reservoirs of an urbanized area. RESULTS: A high rate of infection was found in small mammals (64.9%) and dogs (DG1 30.4% and DG2 48.6%). The presence of L. infantum and L. braziliensis was detected in small mammals and dogs, and mixed infections by both species were detected in rodents which, to the best of our knowledge, is the first description of this phenomenon in an urban area. Additionally, L. amazonensis was detected in the canine samples. CONCLUSION: The possible role of these animals as a source of infection of the vector of each species of Leishmania identified should not be overlooked and should be taken into account in future control activities. The results of mixed infection by L. braziliensis and L. infantum in cosmopolitan rodents as M. musculus and R. rattus, may have important implications in the context of the control of leishmaniasis in urban areas, especially when considering that these rodents live in close relationship with human dwellings, especially those in more precarious conditions
Keywords: Leishmania
Hosts
Reservoir
Small mammals
Dogs
Mixed-infections
Issue Date: 2015
Publisher: BioMed Central
Citation: FERREIRA, Eduardo de Castro et al. Mixed infection of Leishmania infantum and Leishmania braziliensis in rodents from endemic urban area of the New World. BMC Vet Res., vol. 11, p. 71, 2015
DOI: 10.1186/s12917-015-0392-y
ISSN: 1746-6148
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos




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