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DENGUE IN THE STATE OF RIO GRANDE DO NORTE, BRAZIL, 2010–2012
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Abstract
objective To present results of virological surveillance and epidemiological aspects of dengue in the
State of Rio Grande do Norte, Brazil.
methods A total of 1581 cases, reported from 2010 to 2012 at various health centres in the
state, were analysed by viral isolation and/or RT-PCR for viral detection and typing. To identify
whether different genotypes were circulating in the state during this period, sequencing of the
complete E gene for DENV (1485 bp in length) was performed directly from patient serum
samples.
results All four serotypes of dengue virus circulated in Rio Grande do Norte, with the introduction
of DENV-4 in the state in 2011. In 2012, DENV-4 represented 100% of positive confirmed cases.
53.97% of cases occurred in Natal. Case numbers peaked in April (21%) and May (23%). Genetic
characterisation of circulating strains confirmed the circulation of genotypes V, south-east Asian/
American and II, respectively, for DENV-1, DENV-2 and DENV-4.
conclusions This work furthers a better understanding of dengue viruses in the State of Rio
Grande do Norte. Strengthening control efforts in the region is important considering the impact of
dengue.
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