Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13198
Title: Diarrhea outbreak in Pernambuco, Brazil, associated with a heat-stable cytotoxic enterotoxin produced by Aeromonas caviae
Other Titles: O surto de diarreia em Pernambuco, Brasil é associado com uma enterotoxina citotóxica termo-estável produzida por Aeromonas caviae
Authors: Lopes, Ana Carolina Amaral
Martins, Luciano Moura
Gatti, Maria Silvia Viccari
Reis, Christiane Moura Falavina dos
Hofer, Ernesto
Yano, Tomomasa
Affilliation: Universidade Estadual de Campinas. Departamento de Genética, Evolução e Bioagentes. Campinas, SP, Brasil.
Instituto Adolfo Lutz. Centro de Bacteriologia. Departamento de Doenças Infecciosas. São Paulo, SP, Brasil.
Universidade Estadual de Campinas. Departamento de Genética, Evolução e Bioagentes. Campinas, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.
Abstract: In the present study enterotoxic and cytotoxic activities of twenty Aeromonas caviae strains were examined. They originated from fecal specimens of patients with acute diarrhea during an outbreak in Brazil in 2004. Culture supernatants of fourteen strains (70%) caused fluid accumulation in rabbit ileal intestinal loops and in suckling mice assays, and also showed a cytotoxic activity in Vero and Caco-2 cells. The enterotoxic and cytotoxic factors were heat-stable after culture supernatants treatment at 100 ºC. The results revealed that A. caviae strains produce a putative diarrheagenic virulence factor, a heat-stable cytotoxic enterotoxin that could be linked to the diarrhea outbreak that took place in Brazil.
Keywords: Diarrhea outbreak
Aeromonas caviae
Cytotoxic enterotoxin
Virulence factors
Pernambuco
Brazil
DeCS: Fatores de Virulência
Citotoxinas
Aeromonas caviae
Diarreia
Brazil
Issue Date: 2015
Publisher: Instituto de Medicina Tropical de São Paulo
Citation: LOPES, Ana Carolina Amaral; et al. Diarrhea outbreak in Pernambuco, Brazil, associated with a heat-stable cytotoxic enterotoxin produced by Aeromonas caviae. Rev. Inst. Med. trop. S. Paulo, v.57, n.4, p. 349-351, July/Aug. 2015.
DOI: 10.1590/S0036-46652015000400013
ISSN: 1678-9946
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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