| Author | Cantillo-Barraza, Omar | |
| Author | Garcés, Edilson | |
| Author | Gómez-Palacio, Andrés | |
| Author | Cortés, Luis A. | |
| Author | Pereira, André | |
| Author | Marcet, Paula L. | |
| Author | Jansen, Ana M. | |
| Author | Triana-Chávez, Omar | |
| Access date | 2016-03-22T11:10:48Z | |
| Available date | 2016-03-22T11:10:48Z | |
| Document date | 2015 | |
| Citation | CANTILLO-BARRAZA, Omar; et al. Eco-epidemiological study of an endemic Chagas disease region in northern Colombia reveals the importance of Triatoma maculata (Hemiptera: Reduviidae), dogs and Didelphis marsupialis in Trypanosoma cruzi maintenance. Parasites & Vectors, v.8:482, 10p, 2015. | pt_BR |
| ISSN | 1756-3305 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13223 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Title | Eco-epidemiological study of an endemic Chagas disease region in northern Colombia reveals the importance of Triatoma maculata (Hemiptera: Reduviidae), dogs and Didelphis marsupialis in Trypanosoma cruzi maintenance | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s13071-015-1100-2 | |
| Abstract | Background: In Colombia, Rhodnius prolixus and Triatoma dimidiata are the main domestic triatomine species
known to transmit T. cruzi. However, there are multiple reports of T. cruzi transmission involving secondary vectors.
In this work, we carried out an eco-epidemiological study on Margarita Island, located in the Caribbean region of
Colombia, where Chagas disease is associated with non-domiciliated vectors.
Methods: To understand the transmission dynamics of Trypanosoma cruzi in this area, we designed a comprehensive,
multi-faceted study including the following: (i) entomological evaluation through a community-based insect-surveillance
campaign, blood meal source determination and T. cruzi infection rate estimation in triatomine insects; (ii) serological
determination of T. cruzi prevalence in children under 15 years old, as well as in domestic dogs and synanthropic
mammals; (iii) evaluation of T. cruzi transmission capacity in dogs and Didelphis marsupialis, and (iv) genetic
characterization of T. cruzi isolates targeting spliced-leader intergene region (SL-IR) genotypes.
Results: Out of the 124 triatomines collected, 94 % were Triatoma maculata, and 71.6 % of them were infected
with T. cruzi. Blood-meal source analysis showed that T. maculata feeds on multiple hosts, including humans and
domestic dogs. Serological analysis indicated 2 of 803 children were infected, representing a prevalence of 0.25 %. The
prevalence in domestic dogs was 71.6 % (171/224). Domestic dogs might not be competent reservoir hosts, as inferred
from negative T. cruzi xenodiagnosis and haemoculture tests. However, 61.5 % (8/13) of D. marsupialis, the most
abundant synanthropic mammal captured, were T. cruzi-positive on xenodiagnosis and haemocultures.
Conclusions: This study reveals the role of peridomestic T. maculata and dogs in T. cruzi persistence in this
region and presents evidence that D. marsupialis are a reservoir mediating peridomestic-zoonotic cycles. This
picture reflects the complexity of the transmission dynamics of T. cruzi in an endemic area with non-domiciliated
vectors where active human infection exists. There is an ongoing need to control peridomestic T. maculata
populations and to implement continuous reservoir surveillance strategies with community participation. | pt_BR |
| Affilliation | Universidad de Antioquia UdeA. Grupo BCEL. Medellin, Colombia. | pt_BR |
| Affilliation | Universidad de Antioquia UdeA. Grupo BCEL. Medellin, Colombia. | pt_BR |
| Affilliation | Universidad de Antioquia UdeA. Grupo BCEL. Medellin, Colombia. | pt_BR |
| Affilliation | Secretaría de Salud del Departamento de Bolívar. Unidad de Entomología Médica. Cartagena, Colombia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centers for Disease Control and Prevention (CDC). Division of Parasitic Diseases and Malaria. Entomology Branch. Atlanta, GA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidad de Antioquia UdeA. Grupo BCEL. Medellin, Colombia. | pt_BR |
| Subject | Colombia | pt_BR |
| Subject | Risk factors for Chagas disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Seroprevalence | pt_BR |
| Subject | Dogs | pt_BR |
| Subject | Non-domiciliated vectors | pt_BR |
| DeCS | Doença de Chagas | pt_BR |
| DeCS | Fatores de Risco | pt_BR |
| DeCS | Trypanosoma cruzi | pt_BR |
| DeCS | Soroprevalência | pt_BR |
| DeCS | Cães | pt_BR |
