Author | Bomfim, Larissa Mendes | |
Author | Menezes, Leociley Rocha Alencar | |
Author | Rodrigues, Ana Carolina B. C | |
Author | Dias, Rosane Borges | |
Author | Rocha, Clarissa Araújo Gurgel | |
Author | Soares, Milena Botelho Pereira | |
Author | Santana Neto, Albertino Freitas | |
Author | Nascimento, Magaly Pinto | |
Author | Campos, Adriana F | |
Author | Silva, Lidercia Cavalcanti Ribeiro Cerqueira e | |
Author | Costa, Emmanoel Vilaça | |
Author | Bezerra, Daniel Pereira | |
Access date | 2016-03-22T14:38:02Z | |
Available date | 2016-03-22T14:38:02Z | |
Document date | 2016 | |
Citation | BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016. | pt_BR |
ISSN | 1742-7843 | |
ISSN | 10.1111/bcpt.12488 | |
URI | https://www.arca.fiocruz.br/handle/icict/13240 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Annona | pt_BR |
Subject in Portuguese | Annonaceae | pt_BR |
Subject in Portuguese | Óleos essenciais | pt_BR |
Subject in Portuguese | Citotoxicidade | pt_BR |
Subject in Portuguese | Anticorpos antitumor | pt_BR |
Subject in Portuguese | Microencapsulação | pt_BR |
Subject in Portuguese | Ratos | pt_BR |
Title | Antitumour Activity of the Microencapsulation of Annona | pt_BR |
Type | Article | pt_BR |
Abstract | Annona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study
investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed
with b-cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus
and analysed using GC-MS and GC-FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour
cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil
was demonstrated in mice inoculated with B16-F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%),
spathulenol (18.89%), (E)-b-ocimene (12.46%), a-phellandrene (8.08%), o-cymene (6.24%), germacrene D (3.27%) and a-pinene
(2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was
inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil
increased in vivo tumour growth inhibition (inhibition of 62.66%). | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Chemistry. São Crist ovão, SE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil | pt_BR |
Affilliation | Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil | pt_BR |
Affilliation | Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |