Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13240
Title: Antitumour Activity of the Microencapsulation of Annona
Authors: Bomfim, Larissa Mendes
Menezes, Leociley Rocha Alencar
Rodrigues, Ana Carolina B. C
Dias, Rosane Borges
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Neto, Albertino F. S
Nascimento, Magaly Pinto
Campos, Adriana F
Silva, Lidercia Cavalcanti Ribeiro Cerqueira e
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Crist ovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Annona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with b-cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus and analysed using GC-MS and GC-FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil was demonstrated in mice inoculated with B16-F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%), spathulenol (18.89%), (E)-b-ocimene (12.46%), a-phellandrene (8.08%), o-cymene (6.24%), germacrene D (3.27%) and a-pinene (2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil increased in vivo tumour growth inhibition (inhibition of 62.66%).
keywords: Annona
Annonaceae
Óleos essenciais
Citotoxicidade
Anticorpos antitumor
Microencapsulação
Ratos
Issue Date: 2016
Publisher: Wiley
Citation: BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016.
ISSN: 1742-7843
10.1111/bcpt.12488
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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