Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13369
Title: A genome-wide association study of asthma symptoms in Latin American children
Authors: Costa, Gustavo Nunes de Oliveira
Dudbridge, Frank
Fiaccone, Rosemeire Leovigildo
Silva, Thiago Magalhães da
Conceição, Jackson S. da
Strina, Agostino
Figueiredo, Camila Alexandrina Viana
Magalhães, Wagner Carlos Santos
Rodrigues, Maira Ribeiro
Gouveia, Mateus H
Kehdy, Fernanda de Souza Gomes
Horimoto, Andrea Roseli Vançan Russo
Horta, Bernardo Lessa
Burchard, Esteban G
Yanes, Maria Pino
Navarro, Blanca Del Rio
Romieu, Isabelle
Hancock, Dana B
London, Stephanie
Costa, Maria Fernanda Lima
Pereira, Alexandre C
Tarazona, Eduardo Martins
Rodrigues, Laura Cunha
Barreto, Maurício Lima
Affilliation: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA , Brasil.
London School of Hygiene and Tropical Medicine. Department of Non-communicable Disease Epidemiology. London, UK
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA , Brasil.
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA , Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador,
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas.
Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brasil
Universidade Federal de Pelotas. Programa de Pós Graduação em Epidemiologia. Pelotas, Brasil
University of California. Department of Medicine. San Francisco, USA
University of California. Department of Medicine. San Francisco, USA
National Institute of Environmental Health Sciences. National Institutes of Health. Research Triangle Park. Department of Health and Human Services, Epidemiology Branch. North Carolina, USA
Instituto Nacional de Salud Publica. Cuernavaca, Mexico
Behavioral and Urban Health Program. Research Triangle Institute (RTI) International. Research Triangle Park. North Carolina, USA.
National Institute of Environmental Health Sciences. National Institutes of Health. Research Triangle Park. Department of Health and Human Services, Epidemiology Branch. North Carolina, USA
Fundação Oswaldo Cruz. Instituto de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Instituto de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas.
London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA , Brasil / Fundação Osvaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Bras
Abstract: BACKGROUND: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. METHODS: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Following quality control, 1,877,526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an estimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. RESULTS: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95% CI 1.45-2.18, p-value 2.83 × 10(-8)) and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95% CI 2.02-4.49, p-value 6.68 × 10(-8) and rs8029377, MAF 0.03, OR 2.49, 95% CI 1.76-3.53, p-value 2.45 × 10(-7)). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. CONCLUSIONS: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood.
Keywords: Asthma symptoms
Genome-wide association
Latin America
Children
Issue Date: 2015
Publisher: BioMed Central
Citation: COSTA, G. N. O. A genome-wide association study of asthma symptoms in Latin American children. BMC Genetics, v. 16, p. 141, 2015.
ISSN: 1471-2156
10.1186/s12863-015-0296-7
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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