Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13426
Title: Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community
Authors: Maguire, James H
Hoff, Rodney
Sherlock, Ítalo Rodrigues de Araújo
Guimarães, Armênio Costa
Sleigh, Adrian C
Ramos, Nilson Borges
Mott, Kenneth E
Weller, Thomas H
Affilliation: Harvard School of Public Health. Department of Public Health. Division of Infectious Diseases, Brigham and Women's Hospital. Boston, USA
Harvard School of Public Health. Department of Public Health. Division of Infectious Diseases, Brigham and Women's Hospital. Boston, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Department of Cardiology. Salvador, BA, Brasil
Harvard School of Public Health. Department of Public Health. Division of Infectious Diseases, Brigham and Women's Hospital. Boston, USA
Universidade Federal da Bahia. Department of Cardiology. Salvador, BA, Brasil
Harvard School of Public Health. Department of Public Health. Division of Infectious Diseases, Brigham and Women's Hospital. Boston, USA
Harvard School of Public Health. Department of Public Health. Division of Infectious Diseases, Brigham and Women's Hospital. Boston, USA
Abstract: The evolution of Chagas' cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypanosoma cruzi. Age-specific infection rates indicated that most had become infected before the age of 20 years. On follow-up, it appeared that those persons who developed cardiac lesions did so soon after infection, since the incidence of right bundle branch block and other ventricular conduction defects (VCDs) was also highest before age 20 years. The progressive nature of these lesions was demonstrated by frequent development of additional electrocardiographic abnormalities and high mortality among infected adults with VCDs. In contrast, mortality was low and approximately the same for seropositive and seronegative adults under 60 years who had normal electrocardiograms. Electrocardiography during the early asymptomatic stage of infection was able to distinguish persons with potentially lethal cardiac lesions from those with a benign prognosis.
keywords: Doença de Chagas
Eletrocardiografia
Morbidade
Cardiopatia Chagásica
Trypanosoma cruzi
Humanos
Eletrocardiograma
Adultos
Issue Date: 1987
Publisher: American Heart Association
Citation: MAGUIRE, J. H. et al. Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community. Circulation, v. 75, n. 6, p. 1140-1145, 1987.
ISSN: 0009-7322
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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