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https://www.arca.fiocruz.br/handle/icict/13431
ENCAPSULATION OF CARVACROL, A MONOTERPENE PRESENT IN THE ESSENTIAL OIL OF OREGANO, WITH ß-CYCLODEXTRIN, IMPROVES THE PHARMACOLOGICAL RESPONSE ON CANCER PAIN EXPERIMENTAL PROTOCOLS.
Author
Affilliation
Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Federal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
Abstract
Cancer pain is a major public health problem worldwide due to the strong impact on the quality of life of
patients and side effects of the existing therapeutic options. Monoterpenes, as carvacrol (CARV), have
been extensively studied about their therapeutic properties, especially their importance in the control
of painful conditions and inflammation, which can be improved through the use of inclusion complexes
of b-cyclodextrin (b-CD). We evaluated the effect of encapsulation of CARV in b-CD (CARV/b-CD) on the
nociception induced by tumor cells (Sarcoma 180) in rodents. Inclusion complexes were prepared in two
different procedures and characterized through thermal analysis and scanning electron microscopy.
CARV/b-CD complex was administered (50 mg/kg, p.o.) in mice with tumor on the hind paw and was able
to reduce the hyperalgesia (von Frey) during 24 h, unlike the free CARV (100 mg/kg, p.o.), which promoted
effects until 9 h. Administration on alternate days of complex of CARV/b-CD (12.5–50 mg/kg,
p.o.) reduced hyperalgesia, as well as spontaneous and palpation-induced nociception. However, pure
CARV (50 mg/kg) did not cause significant changes in nociceptive responses. Together, these results produced
evidence that the encapsulation of carvacrol in b-cyclodextrin can be useful for the development of
new options for pain management
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