| Author | Costa, Maria Fernanda Lima | |
| Author | Macinko, James | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Cesar, Cibele Comini | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Magalhães, Wagner Carlos Santos | |
| Author | Horta, Bernardo Lessa | |
| Author | Barreto, Maurício Lima | |
| Author | Costa, Erico Castro | |
| Author | Firmo, Josélia Oliveira Araújo | |
| Author | Proietti, Fernando Augusto | |
| Author | Leal, ThiagoPeixoto | |
| Author | Rodrigues, Maira R | |
| Author | Pereira, Alexandre | |
| Author | Santos, Eduardo Tarazona | |
| Access date | 2016-04-05T18:37:25Z | |
| Available date | 2016-04-05T18:37:25Z | |
| Document date | 2015 | |
| Citation | COSTA, M. F. L. et al. Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Plos One, v. 10, n. 12, p. e0144456, 2015. | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13546 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Mortalidade | pt_BR |
| Subject in Portuguese | Etnografia | pt_BR |
| Subject in Portuguese | Genômica | pt_BR |
| Subject in Portuguese | Grupo de ancestralidade no continente africano | pt_BR |
| Subject in Portuguese | Grupo de ascendência continental européia | pt_BR |
| Subject in Portuguese | Condições socioeconômicas | pt_BR |
| Title | Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0144456 | |
| Abstract | BACKGROUND: Self-rated health (SRH) has strong predictive value for mortality in different contexts and cultures, but there is inconsistent evidence on ethnoracial disparities in SRH in Latin America, possibly due to the complexity surrounding ethnoracial self-classification. MATERIALS/METHODS: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual genomic proportions of African, European and Native American ancestry, and ethnoracial self-classification, with baseline and 10-year SRH trajectories in 1,311 community dwelling older Brazilians. We also examined whether genomic ancestry and ethnoracial self-classification affect the predictive value of SRH for subsequent mortality. RESULTS: European ancestry predominated among participants, followed by African and Native American (median = 84.0%, 9.6% and 5.3%, respectively); the prevalence of Non-White (Mixed and Black) was 39.8%. Persons at higher levels of African and Native American genomic ancestry, and those self-identified as Non-White, were more likely to report poor health than other groups, even after controlling for socioeconomic conditions and an array of self-reported and objective physical health measures. Increased risks for mortality associated with worse SRH trajectories were strong and remarkably similar (hazard ratio ~3) across all genomic ancestry and ethno-racial groups. CONCLUSIONS: Our results demonstrated for the first time that higher levels of African and Native American genomic ancestry-and the inverse for European ancestry-were strongly correlated with worse SRH in a Latin American admixed population. Both genomic ancestry and ethnoracial self-classification did not modify the strong association between baseline SRH or SRH trajectory, and subsequent mortality. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | University of California. Fielding School of Public Health. Departments of Health Policy and Management and Community Health Sciences. Los Angeles, California, USA | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Estatística. Belo Horizonte, MG, Brasil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil | |
| Affilliation | Universidade Federal de Pelotas. Departamento de Medicina Social. Pelotas, RGS, Brasil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil | |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil | |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil | |
| Affilliation | Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brazil | |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
