Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13546
Title: Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
Authors: Costa, Maria Fernanda Lima
Macinko, James
Mambrini, Juliana Vaz de Melo
Cesar, Cibele Comini
Peixoto, Sérgio William Viana
Magalhães, Wagner Carlos Santos
Horta, Bernardo Lessa
Barreto, Maurício Lima
Costa, Erico Castro
Firmo, Josélia Oliveira Araújo
Proietti, Fernando Augusto
Leal, ThiagoPeixoto
Rodrigues, Maira R
Pereira, Alexandre
Santos, Eduardo Tarazona
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
University of California. Fielding School of Public Health. Departments of Health Policy and Management and Community Health Sciences. Los Angeles, California, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
Universidade Federal de Minas Gerais. Departamento de Estatística. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
Universidade Federal de Pelotas. Departamento de Medicina Social. Pelotas, RGS, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recide, PE, Brasil
Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brazil
Universidade Federal de Minas Gerais. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
Abstract: BACKGROUND: Self-rated health (SRH) has strong predictive value for mortality in different contexts and cultures, but there is inconsistent evidence on ethnoracial disparities in SRH in Latin America, possibly due to the complexity surrounding ethnoracial self-classification. MATERIALS/METHODS: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual genomic proportions of African, European and Native American ancestry, and ethnoracial self-classification, with baseline and 10-year SRH trajectories in 1,311 community dwelling older Brazilians. We also examined whether genomic ancestry and ethnoracial self-classification affect the predictive value of SRH for subsequent mortality. RESULTS: European ancestry predominated among participants, followed by African and Native American (median = 84.0%, 9.6% and 5.3%, respectively); the prevalence of Non-White (Mixed and Black) was 39.8%. Persons at higher levels of African and Native American genomic ancestry, and those self-identified as Non-White, were more likely to report poor health than other groups, even after controlling for socioeconomic conditions and an array of self-reported and objective physical health measures. Increased risks for mortality associated with worse SRH trajectories were strong and remarkably similar (hazard ratio ~3) across all genomic ancestry and ethno-racial groups. CONCLUSIONS: Our results demonstrated for the first time that higher levels of African and Native American genomic ancestry-and the inverse for European ancestry-were strongly correlated with worse SRH in a Latin American admixed population. Both genomic ancestry and ethnoracial self-classification did not modify the strong association between baseline SRH or SRH trajectory, and subsequent mortality.
keywords: Mortalidade
Etnografia
Genômica
Grupo de ancestralidade no continente africano
Grupo de ascendência continental européia
Condições socioeconômicas
Issue Date: 2015
Publisher: Public Library of Science
Citation: COSTA, M. F. L. et al. Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. Plos One, v. 10, n. 12, p. e0144456, 2015.
DOI: 10.1371/journal.pone.0144456
ISSN: 1932-6203
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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