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A WOLBACHIA SYMBIONT IN AEDES AEGYPTI LIMITS INFECTION WITH DENGUE, CHIKUNGUNYA, AND PLASMODIUM
Moreira, Luciano Andrade et al. | Date Issued: 2009
Author
Moreira, Luciano Andrade
Iturbe-Ormaetxe, Iñaki
Jeffery, Jason A.
Lu, Guangjin
Pyke, Alyssa T.
Hedges, Lauren M.
Rocha, Bruno Coelho
Hall-Mendelin, Sonja
Day, Andrew
Riegler, Markus
Hugo, Leon E.
Johnson, Karyn N.
Kay, Brian H.
McGraw, Elizabeth A.
Hurk, Andrew F. van den
Ryan, Peter A.
O'Neill, Scott L.
Affilliation
University of Queensland. School of Biological Sciences. Brisbane, Australia/ Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
University of Queensland. School of Biological Sciences. Brisbane, Australia
Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia
Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia
Virology, Queensland Health Forensic and Scientific Services. Coopers Plains, Australia
University of Queensland. School of Biological Sciences. Brisbane, Australia
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
University of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia
University of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia
University of Queensland. School of Biological Sciences. Brisbane, Australia/University of Western Sydney. Centre for Plants and the Environment, School of Natural Sciences. Penrith South DC, NSW, Australia
Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia
University of Queensland. School of Biological Sciences. Brisbane, Australia
Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia
University of Queensland. School of Biological Sciences. Brisbane, Australia
Virology, Queensland Health Forensic and Scientific Services. Coopers Plains, Australia/niversity of Queensland. School of Chemical and Molecular Biosciences. Brisbane, Australia
Queensland Institute of Medical Research. Post Office Royal Brisbane Hospital. Brisbane, Australia
University of Queensland. School of Biological Sciences. Brisbane, Australia
Abstract
Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.
Keywords
Humdisease
Molimmuno
 
Publisher
Cell Press
Citation
MOREIRA, Luciano Andrade et al. A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium. Cell., vol.139, n. 7, p. 1268-78, 2009.
DOI
10.1016/j.cell.2009.11.042
ISSN
0092-8674