Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13727
Title: Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential
Authors: Zouache, Karima
Fontaine, Albin
Vega-Rua, Anubis
Mousson, Laurence
Thiberge, Jean-Michel
Oliveira, Ricardo Lourenço de
Caro, Valérie
Lambrechts, Louis
Failloux, Anna-Bella
Affilliation: Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors Laboratory. Paris, France.
Institut Pasteur. Centre National de la Recherche Scientifique. Department of Genomes and Genetics. Paris, France / Institut de Recherche Biomédicale des Armées (IRBA). Unite´ d’Entomologie. Brétigny-sur-Orge, France.
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors Laboratory. Paris, France / Université Pierre et Marie Curie. Cellule Pasteur UPMC. Paris, France.
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors Laboratory. Paris, France.
Institut Pasteur. Genotyping of Pathogens and Public Health. Paris, France.
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors Laboratory. Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborato´rio de Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
Institut Pasteur. Genotyping of Pathogens and Public Health. Paris, France.
Abstract: Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (208C and 288C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G G E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge.
Keywords: Mosquito
Arbovirus
Chikungunya
Temperature
Transmission
Interaction
keywords: Chikungunya
Arbovirus
Temperatura
Interação
Issue Date: 2014
Publisher: Royal Society, The
Citation: ZOUACHE, Karima; et al. Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential. Proceedings of the Royal Society B, v.281, n.1792, 9p, Oct. 2014.
DOI: 10.1098/rspb.2014.1078
ISSN: 0962-8452
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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