Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13770
Title: Insecticidal activity of Leptodactylus knudseni and Phyllomedusa vaillantii crude skin secretions against the mosquitoes Anopheles darlingi and Aedes aegypti
Authors: Trindade, Frances T.T.
Soares, Ângela A.
Moura, Andréa A. de
Rego, Tiago B.
Soares, Andreimar M.
Stábeli, Rodrigo G.
Calderon, Leonardo A.
Silva, Alexandre de Almeida e
Affilliation: Federal University of Rondônia. Department of Biology. Laboratory of Insect Bioecology. Porto Velho, RO, Brazil. / Oswaldo Cruz Foundation. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Porto Velho, RO, Brazil. / Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Oswaldo Cruz Foundation. Porto Velho, RO, Brazil. / Oswaldo Cruz Foundation. Center for the Study of Biomolecules Applicable to Health. Department of Medicine. Federal University of Rondônia. Porto Velho, RO, Brazil.
Federal University of Rondônia. Department of Biology. Laboratory of Insect Bioecology. Porto Velho, RO, Brazil. / Oswaldo Cruz Foundation. Porto Velho, RO, Brazil.
Abstract: Background: Mosquitoes are important vectors of several diseases, including malaria and dengue, and control measures are mostly performed using chemical insecticides. Unfortunately, mosquito resistance to commonly applied insecticides is widespread. There fore, a prospection for new molecules with insecticidal activity based on Amazon biodiversity using the anurans Leptodactylus knudseni and Phyllomedusa vaillantii was performed against the mosquito species Anopheles darlingi and Aedes aegypti. Methods: The granular secretion from anuran skin was obtained by manual stimulation, and lethal concentrations (LCs) for larvicidal and adulticidal tests were calculated using concentrations from 1-100 ppm. The skin secretions from the anuran species tested caused significant mortality within the first 24 hours on adults and larvae, but differed within the mosquito species. Results: The skin secretions from the anuran species tested caused significant mortality within the first 24 hours on adults and larvae, but differed within the mosquito species. The calculated LC50 of L. knudseni skin secretions against An. darlingi was 0.15 and 0.2 ppm for adults and larvae, respectively, but much higher for Ae. aegypti, i.e., 19 and 38 ppm, respectively. Interestingly, the calculated LCs50 of P. vaillantii against both mosquito species in adults were similar, 1.8 and 2.1 ppm, respectively, but the LC50 for An. darlingi larvae was much lower (0.4 ppm) than for Ae aegypti (2.1 ppm). Conclusions: The present experiments indicate that skin secretions from L. knudseni and P. vaillantii contain bioactive molecules with potent insecticide activity. The isolation and characterization of skin secretions components will provide new insights for potential insecticidal molecules.
Keywords: Vector control
Anuran amphibians
Dengue
Malaria
Issue Date: 2014
Publisher: Journal of Venomous Animals and Toxins including Tropical Diseases
Citation: Silva, A. A., et al. Insecticidal activity of Leptodactylus knudseni and Phyllomedusa vaillantii crude skin secretions against the mosquitoes Anopheles darlingi and Aedes aegypti. The Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 20, p. 28, 2014.
DOI: doi:10.1186/1678-9199-20-28
Copyright: open access
Appears in Collections:RO - Artigos de Periódicos

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