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Title: Breeding structure of the sand fly Lutzomyia longipalpis (Lutz & Neiva) in Brazil
Authors: Mutebi, John Paul
Alexander, John Bruce
Sherlock, Ítalo Rodrigues de Araújo
Wellington, Jose
Souza, Adelson Alcimar Almeida de
Shaw, Jeffrey Jon
Rangel, Elizabeth Ferreira
Lanzaro, Gregory C.
Affilliation: University of Texas Medical Branch. Center for Tropical Diseases. Department of Pathology. Galveston, Texas.
University of Texas Medical Branch. Center for Tropical Diseases. Department of Pathology. Galveston, Texas.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Núcleo de Pesquisas. Salvador, BA, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.
Universidade Federal do Ceará. Instituto Evandro Chagas. Seção de Parasitologia. Fortaleza, CE, Brasil.
Fundação Serviços Pública. Belém, PA, Brasil.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil.
Abstract: Eleven populations of Lutzomyia longipalpis (Lutz & Neiva), the sand fly vector of Leishmania chagasi, from different areas of Brazil were analyzed for genetic variation at 16 enzyme loci. In this region, the prevalence of visceral leishmaniasis (VL) caused by L. chagasi is spotty and reproductive isolation among populations of Lu. longipalpis has been reported. It is thought that morphologically similar cryptic species with varying vectorial capacity may be responsible for the discontinuous distribution of VL. The aim was to study the genetic structure of populations within this region and to identify demes that may represent sibling species. Genotypic frequencies within populations were in close compliance to Hardy-Weinberg expectations, suggesting there are no sympatric species among these 11 populations. Levels of genetic distance between pairs of populations were very low (< 0.03), consistent with local populations within a single sand fly species. When genotypic frequency data for all populations were pooled, 9 of the 13 polymorphic loci deviated from Hardy-Weinberg expectations, indicating some degree of genetic substructuring. Estimates of effective migration rates (N(e)m) among all populations were low, 2.73, suggesting that gene flow is restricted among populations, which is probably the reason for the observed genetic substructuring.
Keywords: Lutzomyia longipalpis
DeCS: Insetos Vetores/genética
Leishmaniose Visceral/transmissão
Eletroforese em Gel de Amido
Variação Genética/genética
Insetos Vetores/enzimologia
Issue Date: 1999
Publisher: American Society of Tropical Medicine and Hygiene
Citation: MUTUBI, John Paul et al. Breeding structure of the sand fly Lutzomyia longipalpis (Lutz & Neiva) in Brazil. American Journal of Tropical Medicine and Hygiene, v. 61, n. 1, p. 149-157, 1999.
DOI: 10.4269/ajtmh.1999.61.149
ISSN: 0002-9637
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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