Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13973
Title: Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
Authors: Bayer, Avraham
Lennemann, Nicholas J.
Ouyang, Yingshi
Bramley, John. C.
Morosky, Stefanie
Jr Marques, Ernesto Torres de Azevedo
Cherry, Sara
Sadovsky, Yoel
Coyne, Carolyn B.
Affilliation: University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA.
University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA.
University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PA, USA / Fundação Osvaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.
University of Pennsylvania. Department of Microbiology. Philadelphia, PA, USA.
University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA / University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA / University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, Pittsburgh, PA, USA.
Abstract: During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly and other anomalies suggests that ZIKV may bypass the placenta to reach the fetus. This led us to investigate ZIKV infection of primary human trophoblasts (PHTs), which are the barrier cells of the placenta. We discovered that PHT cells from full-term placentas are refractory to ZIKV infection. In addition, medium from uninfected PHT cells protects non-placental cells from ZIKV infection. PHT cells constitutively release the type III interferon (IFN) IFNl1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophoblast cells from ZIKV infection. Our data suggest that for ZIKV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNl1 and other trophoblast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.
Keywords: Zika Virus
Infectious Disease
Infectious by Zika Virus
Human Placental Trophoblasts
keywords: Vírus Zika
Epidemia
Infecção pelo Vírus Zika
DeCS: Zika virus
Epidemia
Issue Date: 2016
Publisher: Elsevier
Citation: BAYER, Avraham; LENNEMANN, Nicholas J.; OUYANG, Yingshi; BRAMLEY, John C.; MOROSKY, Stefanie; MARQUES JR., Ernesto Torres de Azevedo; CHERRY, Sara; SADOVSKY, Yoel; COYNE, Carolyn B. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host and Microbe, p. 1-8, Apr 5, 2016.
DOI: 10.1016/j.chom.2016.03.008
ISSN: 1931-3128
Embargo date: 2017-04-05
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos




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