| Author | Bhattacharyya, Tapan | |
| Author | Mills, Emily A. | |
| Author | Jansen, Ana Maria | |
| Author | Miles, Michael A. | |
| Access date | 2016-05-10T11:59:02Z | |
| Available date | 2016-05-10T11:59:02Z | |
| Document date | 2015 | |
| Citation | BHATTACHARYYA, Tapan; et al. Prospects for T. cruzi lineage-specific serological surveillance of wild mammals. Acta Tropica, v.151, p.182-186, Nov. 2015. | pt_BR |
| ISSN | 0001-706X | |
| URI | https://www.arca.fiocruz.br/handle/icict/14141 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Reservatório | pt_BR |
| Subject in Portuguese | Linhagem específica | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Sorologia | pt_BR |
| Subject in Portuguese | Mamíferos selvagens | pt_BR |
| Title | Prospects for T. cruzi lineage-specific serological surveillance of wild mammals | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2015.06.017 | |
| Abstract | Sequence diversity in the Trypanosoma cruzi small surface molecule TSSA has yielded antigens for serology to investigate the T. cruzi lineage-specific infection history of patients with Chagas disease. Synthetic peptides can be used as the lineage-specific antigens. Here we consider the rationale, feasibility and potential of applying peptide-based lineage-specific serology to naturally infected wild mammals. The commercial availability of appropriate secondary antibodies encourages this further development, for discovery of new reservoir host species and to reveal the wider ecological distribution of T. cruzi lineages, currently hindered by the need to recover live isolates or to attempt genotyping of DNA extracted from blood samples. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Disease. London, United Kingdom. | pt_BR |
| Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Disease. London, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. b Laboratório de Biologia de Tripanosomatídeos. Pavilhão Rocha Lima. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. b Laboratório de Biologia de Tripanosomatídeos. Pavilhão Rocha Lima. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Lineage-specific | pt_BR |
| Subject | Reservoir | pt_BR |
| Subject | Serology | pt_BR |
| Subject | Silvatic | pt_BR |
| Subject | TSSA | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
