Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14141
Title: Prospects for T. cruzi lineage-specific serological surveillance of wild mammals
Authors: Bhattacharyya, Tapan
Mills, Emily A.
Jansen, Ana Maria
Miles, Michael A.
Affilliation: London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Disease. London, United Kingdom.
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Disease. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. b Laboratório de Biologia de Tripanosomatídeos. Pavilhão Rocha Lima. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. b Laboratório de Biologia de Tripanosomatídeos. Pavilhão Rocha Lima. Rio de Janeiro, RJ, Brasil.
Abstract: Sequence diversity in the Trypanosoma cruzi small surface molecule TSSA has yielded antigens for serology to investigate the T. cruzi lineage-specific infection history of patients with Chagas disease. Synthetic peptides can be used as the lineage-specific antigens. Here we consider the rationale, feasibility and potential of applying peptide-based lineage-specific serology to naturally infected wild mammals. The commercial availability of appropriate secondary antibodies encourages this further development, for discovery of new reservoir host species and to reveal the wider ecological distribution of T. cruzi lineages, currently hindered by the need to recover live isolates or to attempt genotyping of DNA extracted from blood samples.
Keywords: Lineage-specific
Reservoir
Serology
Silvatic
TSSA
Trypanosoma cruzi
keywords: Reservatório
Linhagem específica
Trypanosoma cruzi
Sorologia
Mamíferos selvagens
Issue Date: 2015
Publisher: Elsevier
Citation: BHATTACHARYYA, Tapan; et al. Prospects for T. cruzi lineage-specific serological surveillance of wild mammals. Acta Tropica, v.151, p.182-186, Nov. 2015.
DOI: 10.1016/j.actatropica.2015.06.017
ISSN: 0001-706X
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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