Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14252
Title: Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)
Authors: Silva, Thanany Brasil da
Menezes, Leociley Rocha Alencar
Sampaio, Marília Fernanda Chaves
Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Prata, Ana Paula do Nascimento
Nogueira, Paulo Cesar de Lima
Costa, Emmanoel Vilaça
Affilliation: Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Biologia. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil
Abstract: Essential oils from leaves of Xylopia frutescens (XFMJ) and two specimens of Xylopia laevigata (XLMC and XLSI) were obtained by hydrodistillation using a Clevenger-type apparatus, and analyzed by GC-MS and GC-FID. Sesquiterpenes dominated the essential oils. The main constituents of XFMJ were (E)-caryophyllene (24.8%), bicyclogermacrene (20.8%), germacrene D (17.0%), -elemene (7.9%), and (E)--ocimene (6.8%). XLMC contained significant quantities of germacrene D (18.9%), bicyclogermacrene (18.4%), -elemene (9.5%), -selinene (9.2%), (E)-caryophyllene (8.5%), germacrene B (5.7%) and -muurolene (5.7%), while germacrene D (27.0%), bicyclogermacrene (12.8%), (E)-caryophyllene (8.6%), -muurolene (8.6%), -cadinene (6.8%), and germacrene B (6.0%) were the main components of XLSI. The essential oils had trypanocidal activity against the Y strain of Trypanosoma cruzi, with IC50 values lower than 30 μg.mL-1 and 15 μg.mL-1 against epimastigote and trypomastigote forms of T. cruzi, respectively, and were also able to reduce the percentage in vitro of T. cruzi-infected macrophages and the intracellular number of amastigotes at concentrations that were non-cytotoxic to macrophages
Keywords: Xylopia frutescens
Xylopia laevigata
Essential oil
Trypanocidal activity
Issue Date: 2013
Publisher: Natural Product Communications
Citation: SILVA, T. B. et al. Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, v. 8, n. 3, p. 403-406, 2013.
ISSN: 1934-578X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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