Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14257
Title: Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
Authors: Macedo, Carolina Thé
Larocca, Ticiana Ferreira
Rabelo, Márcia Noya
Correia, Luís Cláudio Lemos
Moreira, Moisés Imbassahy Guimarães
Caldas, Alessandra Carvalho
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Affilliation: Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Background: One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imagingmodalitywith useful applications in several cardiac diseases, has been validated for subjects with myocardial infarction against cardiac magnetic resonance (CMR). Here we hypothesize that the longitudinal global strain (LGS) has an incremental value to ejection fraction for predicting myocardial fibrosis in subjects with Chagas disease. Methods: This observational study comprised 58 subjectswith Chagas disease, confirmed by two positive serologic tests. All subjects underwent conventional Doppler echocardiogramplus speckle tracking strain, and cardiacmagnetic resonance. Results: The ROC curve analysis revealed that both LGS (area under the curve: 0.78, p=0.001) and ejection fraction (area under the curve: 0.82, p b 0.001)were significant predictors ofmyocardial fibrosis. Regarding the percentage of fibrosis, a high correlation was observed with both ejection fraction assessed by echocardiography (r =0.70, p b 0.001) and LGS (r = 0.64, p b 0.001). However, when adjusted through multiple linear regression, the LGS lost statistical significance as a predictor of myocardial fibrosis (p = 0.111). Conclusions: LGS has no incremental value to conventional ejection fractionmeasurement in the prediction ofmyocardial fibrosis in subjects with Chagas disease.
Keywords: Speckle tracking
Chagas disease
Longitudinal global strain
Issue Date: 2015
Publisher: Elsevier
Citation: MACEDO, C. T. et al. Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease. IJC Heart & Vasculature, v. 8, p. 75–80, 2015.
DOI: /dx.doi.org/10.1016/j.ijcha.2015.05.007
ISSN: 2352-9067
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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