Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14262
Title: Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
Authors: Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Macedo, Taís Soares
Silva, Thanany Brasil da
Menezes, Leociley Rocha Alencar
Costa, Emmanoel Vilaça
Soares, Milena Botelho Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil
Universidade Federal de Sergipe. Departamento de Química. Itabaiana, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Abstract: Here, we describe the trypanocidal and antimalarial activities from essential oils extracted from Annona vepretorum (AVOE) and Annona squamosa (ASOE) (Annonaceae) leaves. The essential oils were obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC–MS) and GC–flame ionization detection (GC–FID). A total of twenty-one compounds were identified in AVOE and twenty-three in ASOE. The sesquiterpenes are more abundant in the both essential oils. ASOE contained significant quantities of (E)-caryophyllene (27.4%), germacrene D (17.1%) and bicyclogermacrene (10.8%). The major compounds in AVOE were bicyclogermacrene (39.0%), spathulenol (14.0%) and α-phellandrene (11.5%). The essential oils demonstrated potent trypanocidal and antimalarial activities with values of IC50 lower than 20 μg/mL, and a strong inhibition of the proliferation of amastigotes, the clinically relevant forms of Trypanosoma cruzi. In addition, through ultrastructural studies and flow cytometry analysis with trypomastigotes of T. cruzi, we identified significant ultrastructural alterations induced by the essential oils, especially in the cell membrane and mitochondria, which ultimately results in necrotic parasite death
Keywords: Annona squamosa
Annona vepretorum
Essential oil
Antimalarial activity; trypanocidal activity
Issue Date: 2015
Publisher: Taylor & Francis
Citation: MEIRA, C. S. et al. Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities. Journal of Essential Oil Research, v. 27, n. 2, p. 160–168, 2015.
DOI: dx.doi.org/10.1080/10412905.2014.982876
ISSN: 1041-2905
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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