Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14584
Title: Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
Authors: Souza, Nicolli Bellotti de
Aguiar, Anna Caroline Campos
Oliveira, Alane Cabral de
Top, Siden
Pigeon, Pascal
Jaouen, Gérard
Goulart, Marilia Oliveira Fonseca
Krettli, Antoniana Ursine
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil / Universidade Federal de Alagoas. Faculdade de Nutrição. Maceió, AL, Brasil.
Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France.
Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France / Ecole Nationale Supérieure de Chimie de Paris. Paris, France.
Sorbonne Universités. Université Pierre-et-Marie-Curie. Unités Mixtes de Recherche. Paris, France / Ecole Nationale Supérieure de Chimie de Paris. Paris, France.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Abstract: This work reports the in vitro activity against Plasmodium falciparum blood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.
Keywords: Plasmodium falciparum
Metallodrug activity
Ruthenocifens
Ferrocifens
Issue Date: 2015
Publisher: Fundação Oswaldo Cruz
Citation: SOUZA, Nicolli Bellotti de et al. Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 8, p. 981-988, Dec. 2015.
DOI: 10.1590/0074-02760150163
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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