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Title: Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
Authors: Andrade, Sonia Gumes
Grimaud, Jean Alexis
Affilliation: Fundação Gonçalo Moniz, Instituto de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur de Lyon. Lyon, France
Abstract: In na attempt to define the mouse-model for chronic Chagas' disease, a serological, histopathological and ultrastructural study as well as immunotyping of myocardium collagenic matrix were performed on Swiss mice, chronically infected with Trypanosoma cruzi strains: 21 SF and Mambaí (Type II); PMN and Bolívia (Type III), spontaneously surviving after 154 to 468days of infection. Haemagglutination and indirect immunofluorescence tests showed high titres of specific antibodies. The ultrastructural study disclosed the cellular constitution of the inflammatory infiltrate showing the predominance of monocytes, macrophages with intense phagocytic activity, fibroblasts, myofibroblasts and abundant collagen matrix suggesting the association of the inflammatory process with fibrogenesis in chronic chagasic cardiomyopathy. Arteriolar and blood capillary alterations together with dissociation of cardiac cells from the capillaty wall by edema and inflammation were related to ultrastructural lesions of myocardial cells. Rupture of parasitized cardiac myocells contribute to intensify the inflammatory process in focal areas. Collagen immunotyping showed the predominance of Types III and IV collagen. Collagen degradation and phagocytosis were presente suggesting a reversibility of the fibrous process. The mouse model seems to be valuble in the study of the pathogenetic mechanisms in Chagas cardiomyopathy, providing that T. cruzi strains of low virulence and high pathogenecity are used.
Keywords: Trypanosoma cruzi
Chronic experimental T. cruzi infection
Mouse model of chronic T. cruzi
Chronic myocarditis
Collagen immunolabelling
Ultrastructural myocardial
Issue Date: 1986
Publisher: Instituto Oswaldo Cruz
Citation: ANDRADE, S. G.; GRIMAUD, J. A. Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix. Memórias do Instituto Oswaldo Crux, v. 81, n. 1, p. 29-41, 1986.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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